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Tclin
RET
Proto-oncogene tyrosine-protein kinase receptor Ret

Protein Summary
Description
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340058
  • ENSP00000344798
  • ENSG00000165731
  • ENST00000355710
  • ENSP00000347942

Symbol
  • CDHF12
  • CDHR16
  • PTC
  • RET51
  • PTC
  • MTC1
  • HSCR1
  • MEN2A
  • MEN2B
  • CDHF12
  • CDHR16
  • RET-ELE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
hub protein
0.99
molecular function
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4517.14   (req: < 5)
Gene RIFs: 591   (req: <= 3)
Antibodies: 1078   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4517.14   (req: >= 5)
Gene RIFs: 591   (req: > 3)
Antibodies: 1078   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 274
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15