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Tbio
RERE
Arginine-glutamic acid dipeptide repeats protein

Protein Summary
Description
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337907
  • ENSP00000338629
  • ENSG00000142599
  • ENST00000400908
  • ENSP00000383700
  • ENST00000476556
  • ENSP00000422246

Symbol
  • ARG
  • ARP
  • ATN1L
  • KIAA0458
  • ARG
  • ARP
  • DNB1
  • ATN1L
  • NEDBEH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.96
transcription factor
0.94
protein domain
0.92
kinase perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999921
p_ni:  7.9e-8
Score:  0.777
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999829
p_ni:  2e-9
p_wrong:  1.69e-7
Score:  0.75
Data Source:  BioPlex,STRINGDB
CDO1
Tbio
Family:  Enzyme
Novelty:  0.01682989
p_int:  0.983084257
p_ni:  0.000888562
p_wrong:  0.016027181
Score:  0.29
Data Source:  BioPlex,STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
Score:  0.95
Data Source:  STRINGDB
NR2F1
Tbio
Family:  NR
Novelty:  0.00588095
Score:  0.95
Data Source:  STRINGDB
VWA1
Tbio
Novelty:  0.00212445
Score:  0.887
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.725
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.724
Data Source:  STRINGDB
RARB
Tclin
Family:  NR
Novelty:  0.00257427
Score:  0.676
Data Source:  STRINGDB
NR2E1
Tbio
Family:  NR
Novelty:  0.0184868
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
95.9
5
7
2
5.8
95.8
neutrophil count
3
4
4
94.1
lymphocyte count
3
3
3
90.3
3
3
0
1
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
95.9
2
5.8
95.8
neutrophil count
4
94.1
lymphocyte count
3
90.3
0
1
88.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginine-glutamic acid dipeptide repeats
VGNC:9894
457909
Macaque
arginine-glutamic acid dipeptide repeats
708902
Mouse
MGI:2683486
68703
Rat
RGD:629475
116665
Dog
arginine-glutamic acid dipeptide repeats
VGNC:45477
479596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginine-glutamic acid dipeptide repeats
Macaque
arginine-glutamic acid dipeptide repeats
Mouse
Rat
Dog
arginine-glutamic acid dipeptide repeats
Publication Statistics
PubMed Score 35.73
PubMed score by year
PubTator Score 35.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title