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Tbio
REPS1
RalBP1-associated Eps domain-containing protein 1

Protein Summary
Description
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258062
  • ENSP00000258062
  • ENSG00000135597
  • ENST00000367663
  • ENSP00000356635
  • ENST00000409812
  • ENSP00000386699
  • ENST00000450536
  • ENSP00000392065

Symbol
  • NBIA7
  • RALBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
disease perturbation
0.83
protein domain
0.73
kinase perturbation
0.66
transcription factor binding site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999993
p_ni:  7e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.99999991
p_ni:  9.1e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
p_int:  0.999999846
p_ni:  1.54e-7
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
REPS2
Tbio
Novelty:  0.0741316
p_int:  0.999995566
p_ni:  0.000004263
p_wrong:  1.72e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999990988
p_ni:  0.000009012
Score:  0.977
Data Source:  BioPlex,STRINGDB
BMP2K
Tchem
Family:  Kinase
Novelty:  0.10145601
p_int:  0.999981525
p_ni:  0.000018475
Score:  0.977
Data Source:  BioPlex,STRINGDB
PNMA1
Tbio
Novelty:  0.06899807
p_int:  0.999941578
p_ni:  0.000051123
p_wrong:  0.000007299
Score:  0.183
Data Source:  BioPlex,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.999603571
p_ni:  0.000396429
Score:  0.744
Data Source:  BioPlex,STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
p_int:  0.99948059
p_ni:  0.00051941
Score:  0.93
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999095634
p_ni:  0.000904282
p_wrong:  8.3e-8
Score:  0.681
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albumin:globulin ratio measurement
1
1
1
24.5
high density lipoprotein cholesterol measurement
1
1
1
24.5
1
1
0
1
21.5
serum non-albumin protein measurement
1
1
1
21.5
apolipoprotein A 1 measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albumin:globulin ratio measurement
1
24.5
high density lipoprotein cholesterol measurement
1
24.5
0
1
21.5
serum non-albumin protein measurement
1
21.5
apolipoprotein A 1 measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RALBP1 associated Eps domain containing 1
VGNC:3681
463031
Macaque
RALBP1 associated Eps domain containing 1
702858
Mouse
MGI:1196373
19707
Dog
RALBP1 associated Eps domain containing 1
VGNC:53759
476221
Horse
RALBP1 associated Eps domain containing 1
VGNC:22302
100073201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RALBP1 associated Eps domain containing 1
Macaque
RALBP1 associated Eps domain containing 1
Mouse
Dog
RALBP1 associated Eps domain containing 1
Horse
RALBP1 associated Eps domain containing 1
Publication Statistics
PubMed Score 11.41
PubMed score by year
PubTator Score 4.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title