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Tbio
RENBP
N-acylglucosamine 2-epimerase

Protein Summary
Description
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393700
  • ENSP00000377303
  • ENSG00000102032

Symbol
  • RBP
  • RNBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
co-expressed gene
0.69
tissue sample
0.61
kinase perturbation
0.6
cell type or tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.24   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.24   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
p_int:  0.999921012
p_ni:  1.2e-7
p_wrong:  0.000078868
Score:  0.403
Data Source:  BioPlex,STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.987
Data Source:  STRINGDB
NPL
Tbio
Family:  Enzyme
Novelty:  0.00944797
Score:  0.971
Data Source:  STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
Score:  0.966
Data Source:  STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.941
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.915
Data Source:  STRINGDB
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.915
Data Source:  STRINGDB
CHIT1
Tchem
Family:  Enzyme
Novelty:  0.00113383
Score:  0.902
Data Source:  STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
Score:  0.9
Data Source:  STRINGDB
NAA10
Tbio
Family:  Enzyme
Novelty:  0.00086809
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
77.6
neutrophil percentage of leukocytes
1
1
1
75.5
lymphocyte percentage of leukocytes
1
1
1
74.4
2
2
0
1.6
61.3
albumin:globulin ratio measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77.6
neutrophil percentage of leukocytes
1
75.5
lymphocyte percentage of leukocytes
1
74.4
0
1.6
61.3
albumin:globulin ratio measurement
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
renin binding protein
VGNC:1205
741507
Macaque
renin binding protein
698140
Mouse
MGI:105940
19703
Rat
RGD:621688
81759
Dog
renin binding protein
VGNC:54185
612532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
renin binding protein
Macaque
renin binding protein
Mouse
Rat
Dog
renin binding protein
Publication Statistics
PubMed Score 44.24
PubMed score by year
PubTator Score 31.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title