Protein Summary
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39096.54 (req: < 5)
Gene RIFs: 169 (req: <= 3)
Antibodies: 702 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39096.54 (req: >= 5)
Gene RIFs: 169 (req: > 3)
Antibodies: 702 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2518
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (2518)
Protein-Protein Interactions (260)
TMEM184B
Novelty: 0.35340207
p_int: 0.999999252
p_ni: 7.48e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
BMT2
Family: Enzyme
Novelty: 0.05916379
p_int: 0.995473012
p_ni: 0.004036101
p_wrong: 0.000490887
Score: 0.204
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (28)
Reactome (3)
KEGG (2)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peptide hormone metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of Angiotensinogen to Angiotensins | ||||
Metabolism of proteins | ||||
Peptide hormone metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (4)
Components (5)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Physical Interaction (IPI) | HGNC | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
renin measurement | 1 | 2 | 2 | 95.1 | |||||
testosterone measurement | 4 | 3 | 4 | 93.1 | |||||
hematocrit | 2 | 2 | 2 | 65.3 | |||||
hemoglobin measurement | 1 | 1 | 1 | 46.5 | |||||
platelet count | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
renin measurement | 2 | 95.1 | |||||
testosterone measurement | 4 | 93.1 | |||||
hematocrit | 2 | 65.3 | |||||
hemoglobin measurement | 1 | 46.5 | |||||
platelet count | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | renin | VGNC:6977 | 469651 | |||||
Macaque | renin | 574299 | ||||||
Mouse | MGI:97898 | 19701 | ||||||
Rat | RGD:3554 | 24715 | ||||||
Dog | renin | VGNC:45474 | 403838 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | renin | |||||
Macaque | renin | |||||
Mouse | ||||||
Rat | ||||||
Dog | renin | |||||
Publication Statistics
PubMed Score 39096.54
PubMed score by year
PubTator Score 20228.75
PubTator score by year
Related Publications
Text Mined References (243)
GeneRif Annotations (169)
Items per page:
0 of 0
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