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Tbio
RELN
Reelin

Protein Summary
Description
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343529
  • ENSP00000345694
  • ENSG00000189056
  • ENST00000428762
  • ENSP00000392423

Symbol
  • RL
  • ETL7
  • LIS2
  • PRO1598
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
trait
0.99
gene perturbation
0.96
PubMedID
0.91
biological term
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.17   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.17   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
LRP8
Tbio
Novelty:  0.00473606
Score:  0.996
Data Source:  STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.995
Data Source:  Reactome,STRINGDB
DAB1
Tbio
Novelty:  0.08538222
Score:  0.988
Data Source:  Reactome,STRINGDB
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.978
Data Source:  STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.958
Data Source:  STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
Score:  0.954
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.948
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.946
Data Source:  Reactome,STRINGDB
ITGA3
Tchem
Novelty:  0.00505981
Score:  0.944
Data Source:  STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Reelin signalling pathway
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Reelin signalling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
93.2
body mass index
4
3
4
89.6
brain volume measurement
3
4
4
78.3
body height
1
1
1
66.5
brain measurement
1
1
0
9.7
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
93.2
body mass index
4
89.6
brain volume measurement
4
78.3
body height
1
66.5
brain measurement
0
9.7
65
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reelin
VGNC:4491
463635
Mouse
MGI:103022
19699
Rat
RGD:3553
24718
Dog
reelin
VGNC:45470
483273
Horse
reelin
VGNC:22296
100058621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reelin
Mouse
Rat
Dog
reelin
Horse
reelin
Publication Statistics
PubMed Score 227.17
PubMed score by year
PubTator Score 382.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title