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Tdark
RELCH
RAB11-binding protein RELCH

Protein Summary
Description
Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256858
  • ENSP00000256858
  • ENSG00000134444
  • ENST00000398130
  • ENSP00000381198

Symbol
  • KIAA1468
  • HsT885
  • HsT3308
  • KIAA1468
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
ligand (protein) perturbation
0.83
histone modification site profile
0.8
cell line
0.71
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.9999997
p_ni:  2.99e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.999998278
p_ni:  0.000001722
Score:  0.276
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.990853027
p_ni:  0.009144506
p_wrong:  0.000002467
Score:  0.189
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.955003249
p_ni:  0.044142622
p_wrong:  0.000854128
Data Source:  BioPlex
TANGO6
Tdark
Novelty:  1.20710275
Score:  0.755
Data Source:  STRINGDB
INTS4
Tdark
Novelty:  0.20868831
Score:  0.743
Data Source:  STRINGDB
TOGARAM2
Tdark
Novelty:  0.6237912
Score:  0.741
Data Source:  STRINGDB
RSPH14
Tdark
Novelty:  0.53463266
Score:  0.731
Data Source:  STRINGDB
PPP4C
Tbio
Family:  Enzyme
Novelty:  0.00705824
Score:  0.709
Data Source:  STRINGDB
HEATR6
Tbio
Novelty:  0.02692882
Score:  0.708
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
6
91.6
alkaline phosphatase measurement
2
1
1
14.5
83.7
bone density
5
2
7
70.5
3
1
2
1
61.4
age at onset
2
1
1
1.1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
91.6
alkaline phosphatase measurement
1
14.5
83.7
bone density
7
70.5
2
1
61.4
age at onset
1
1.1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA1468
VGNC:5176
455456
Macaque
KIAA1468 ortholog
699478
Mouse
MGI:1922832
227446
Rat
RGD:1307235
309053
Dog
RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
VGNC:42368
476181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA1468
Macaque
KIAA1468 ortholog
Mouse
Rat
Dog
RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Publication Statistics
PubMed Score 2.88
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title