Protein Summary
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various ...more
- ENST00000308639
- ENSP00000311508
- ENSG00000173039
- ENST00000406246
- ENSP00000384273
- NFKB3
- p65
- CMCU
- NFKB3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1509.21 (req: < 5)
Gene RIFs: 861 (req: <= 3)
Antibodies: 3431 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1509.21 (req: >= 5)
Gene RIFs: 861 (req: > 3)
Antibodies: 3431 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 101
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 28
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (28)
Protein-Protein Interactions (588)
NFKBIA
Novelty: 0.00022873
p_int: 0.999999997
p_ni: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NFKBIB
Novelty: 0.00517222
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
REL
Family: TF
Novelty: 0.00038265
p_int: 0.999999755
p_ni: 2.45e-7
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
RELB
Family: TF
Novelty: 0.00216805
p_int: 0.999999545
p_ni: 4.55e-7
Score: 0.974
Data Source: BioPlex,Reactome,STRINGDB
C2orf27A
Novelty: 2.91059359
p_int: 0.999707622
p_ni: 0.000292375
p_wrong: 2e-9
Data Source: BioPlex
FBXW11
Novelty: 0.0715377
p_int: 0.99920131
p_ni: 0.00079869
Score: 0.916
Data Source: BioPlex,Reactome,STRINGDB
BTRC
Novelty: 0.00293475
p_int: 0.997572044
p_ni: 0.002427956
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
NUFIP2
Novelty: 0.09366649
p_int: 0.948716992
p_ni: 0.051172321
p_wrong: 0.000110687
Score: 0.226
Data Source: BioPlex,STRINGDB
LINC01587
Novelty: 0.48128342
p_int: 0.940429022
p_ni: 0.059570971
p_wrong: 7e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
DAPP1
Novelty: 0.05145215
p_int: 0.905464869
p_ni: 0.089771172
p_wrong: 0.004763959
Data Source: BioPlex
Nearest Tclin Targets (13)
Upstream (4)
Downstream (9)
1 – 4 of 4
IL1R1
Pathways (239)
Reactome (70)
KEGG (66)
PathwayCommons (47)
WikiPathways (56)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of NF-kappaB in B cells | ||||
Reactome | Adaptive Immune System | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CD209 (DC-SIGN) signaling | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of NF-kappaB in B cells | ||||
Adaptive Immune System | ||||
C-type lectin receptors (CLRs) | ||||
CD209 (DC-SIGN) signaling | ||||
CLEC7A (Dectin-1) signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (109)
Functions (29)
Components (8)
Processes (72)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 4 | 5 | 97.8 | |||||
glomerular filtration rate | 4 | 5 | 5 | 9.3 | 95 | ||||
heel bone mineral density | 3 | 5 | 7 | 95 | |||||
urate measurement | 4 | 5 | 6 | 94.9 | |||||
mean platelet volume | 3 | 2 | 3 | 93.2 | |||||
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 5 | 97.8 | |||||
glomerular filtration rate | 5 | 9.3 | 95 | ||||
heel bone mineral density | 7 | 95 | |||||
urate measurement | 6 | 94.9 | |||||
mean platelet volume | 3 | 93.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | RELA proto-oncogene, NF-kB subunit | VGNC:10283 | 466665 | |||||
Macaque | RELA proto-oncogene, NF-kB subunit | 715919 | ||||||
Mouse | MGI:103290 | 19697 | ||||||
Rat | RGD:727889 | 309165 | ||||||
Dog | RELA proto-oncogene, NF-kB subunit | VGNC:45466 | 483729 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | RELA proto-oncogene, NF-kB subunit | |||||
Macaque | RELA proto-oncogene, NF-kB subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | RELA proto-oncogene, NF-kB subunit | |||||
Publication Statistics
PubMed Score 1509.21
PubMed score by year
PubTator Score 2856.78
PubTator score by year
Related Publications
Text Mined References (1126)
GeneRif Annotations (861)
Items per page:
0 of 0
PMID | Year | Title |
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