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Tbio
REEP6
Receptor expression-enhancing protein 6

Protein Summary
Description
May play a role in intracellular protein transport from the endoplasmic reticulum to the cell surface (By similarity). Required for correct function and survival of retinal photoreceptors (PubMed:27889058). The protein encoded by this gene may be involved in the transport of receptors from the endoplasmic reticulum (ER) to the cell surface. The encoded protein may also play a role in regulating ER membrane structure. This gene is required for the proper development of retinal rods and photoreceptors, with defects in this gene being associated with retinitis pigmentosa 77. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233596
  • ENSP00000233596
  • ENSG00000115255

Symbol
  • C19orf32
  • DP1L1
  • RP77
  • DP1L1
  • TB2L1
  • Yip2f
  • REEP6.1
  • REEP6.2
  • C19orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
histone modification site profile
0.75
transcription factor perturbation
0.68
cell type or tissue
0.63
small molecule perturbation
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (450)
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999986232
p_ni:  0.000013768
Score:  0.657
Data Source:  BioPlex,STRINGDB
PLP1
Tbio
Novelty:  0.00129083
p_int:  0.999957291
p_ni:  0.000042709
Score:  0.303
Data Source:  BioPlex,STRINGDB
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.999952679
p_ni:  0.000047321
Score:  0.195
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.999936527
p_ni:  0.000063473
Data Source:  BioPlex
C20orf141
Tdark
Novelty:  7
p_int:  0.999907276
p_ni:  0.000092724
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999475895
p_ni:  0.000524095
p_wrong:  1e-8
Data Source:  BioPlex
IL2RG
Tclin
Novelty:  0.00108272
p_int:  0.999339747
p_ni:  0.000463826
p_wrong:  0.000196427
Score:  0.295
Data Source:  BioPlex,STRINGDB
TMEM208
Tdark
Novelty:  0.63059333
p_int:  0.999337469
p_ni:  0.000662529
p_wrong:  2e-9
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.997865197
p_ni:  0.002133356
p_wrong:  0.000001448
Data Source:  BioPlex
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.997766529
p_ni:  0.002232919
p_wrong:  5.52e-7
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
22.5
hematocrit
1
1
1
10.7
hemoglobin measurement
1
1
1
10.7
Urinary retention
1
1
0
7.8
10.1
response to radiation
1
1
0
7.8
10.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
22.5
hematocrit
1
10.7
hemoglobin measurement
1
10.7
Urinary retention
0
7.8
10.1
response to radiation
0
7.8
10.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917585
70335
Rat
RGD:1309508
362835
Dog
receptor accessory protein 6 [Source:HGNC Symbol;Acc:HGNC:30078]
Cow
receptor accessory protein 6
VGNC:33856
522480
Pig
receptor accessory protein 6
100626712
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
receptor accessory protein 6 [Source:HGNC Symbol;Acc:HGNC:30078]
Cow
receptor accessory protein 6
Pig
receptor accessory protein 6
Publication Statistics
PubMed Score 14.69
PubMed score by year
PubTator Score 3.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title