You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
REEP4
Receptor expression-enhancing protein 4

Protein Summary
Description
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306306
  • ENSP00000303482
  • ENSG00000168476
  • ENST00000334530
  • ENSP00000333889

Symbol
  • C8orf20
  • PP432
  • Yip2c
  • C8orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.82
tissue sample
0.64
disease perturbation
0.56
transcription factor binding site profile
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (419)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999891426
p_ni:  0.000108574
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999617962
p_ni:  0.000382035
p_wrong:  3e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.99914514
p_ni:  0.00085486
Score:  0.211
Data Source:  BioPlex,STRINGDB
REEP1
Tbio
Novelty:  0.02280713
p_int:  0.998238079
p_ni:  0.001761883
p_wrong:  3.8e-8
Score:  0.702
Data Source:  BioPlex,STRINGDB
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.996023654
p_ni:  0.003975795
p_wrong:  5.51e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
SLC44A5
Tdark
Family:  Transporter
Novelty:  0.15262166
p_int:  0.981596546
p_ni:  0.018403116
p_wrong:  3.38e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
SLC8A3
Tchem
Family:  Transporter
Novelty:  0.01041945
p_int:  0.977915709
p_ni:  0.020403502
p_wrong:  0.001680789
Score:  0.207
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.975562334
p_ni:  0.024437666
Score:  0.513
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.972711654
p_ni:  0.027288269
p_wrong:  7.7e-8
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.963861097
p_ni:  0.036138566
p_wrong:  3.37e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
94.5
serum alanine aminotransferase measurement
2
2
1
7
75
low density lipoprotein cholesterol measurement
4
4
4
74
apolipoprotein B measurement
2
2
2
72.8
3
2
3
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
94.5
serum alanine aminotransferase measurement
1
7
75
low density lipoprotein cholesterol measurement
4
74
apolipoprotein B measurement
2
72.8
3
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 4
VGNC:808
742023
Macaque
receptor accessory protein 4
707267
Mouse
MGI:1919799
72549
Rat
RGD:1306561
306014
Dog
receptor accessory protein 4
VGNC:45463
486129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 4
Macaque
receptor accessory protein 4
Mouse
Rat
Dog
receptor accessory protein 4
Publication Statistics
PubMed Score 3.60
PubMed score by year
PubTator Score 0.90
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title