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Tbio
REEP3
Receptor expression-enhancing protein 3

Protein Summary
Description
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373758
  • ENSP00000362863
  • ENSG00000165476

Symbol
  • C10orf74
  • Yip2b
  • C10orf74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
microRNA
0.88
transcription factor binding site profile
0.85
transcription factor perturbation
0.84
histone modification site profile
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0