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Tbio
REEP1
Receptor expression-enhancing protein 1

Protein Summary
Description
Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000165698
  • ENSP00000165698
  • ENSG00000068615
  • ENST00000453231
  • ENSP00000392197
  • ENST00000535845
  • ENSP00000437567
  • ENST00000541910
  • ENSP00000442681

Symbol
  • C2orf23
  • SPG31
  • HMN5B
  • SPG31
  • Yip2a
  • C2orf23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
transcription factor perturbation
0.8
cellular component
0.71
small molecule perturbation
0.67
microRNA
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (472)
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.99998514
p_ni:  0.000014857
p_wrong:  3e-9
Score:  0.566
Data Source:  BioPlex,STRINGDB
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
p_int:  0.999953375
p_ni:  0.000045553
p_wrong:  0.000001072
Score:  0.196
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.99988346
p_ni:  0.00004487
p_wrong:  0.000071671
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999792003
p_ni:  0.000066016
p_wrong:  0.000141981
Score:  0.527
Data Source:  BioPlex,STRINGDB
REEP4
Tbio
Novelty:  0.37950931
p_int:  0.998238079
p_ni:  0.001761883
p_wrong:  3.8e-8
Score:  0.702
Data Source:  BioPlex,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.986646519
p_ni:  0.013353481
Score:  0.256
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.937408392
p_ni:  0.062591608
Score:  0.17
Data Source:  BioPlex,STRINGDB
REEP2
Tdark
Novelty:  0.23897587
p_int:  0.885992478
p_ni:  2.37e-7
p_wrong:  0.114007286
Score:  0.842
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.849677359
p_ni:  0.150322641
Score:  0.207
Data Source:  BioPlex,STRINGDB
OR1G1
Tdark
Family:  oGPCR
Novelty:  0.10297127
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
9.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
9.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 1
VGNC:350
470514
Mouse
MGI:1098827
52250
Rat
RGD:1305230
362384
Dog
receptor accessory protein 1
VGNC:45460
613003
Cow
receptor accessory protein 1
VGNC:33851
616916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor accessory protein 1
Mouse
Rat
Dog
receptor accessory protein 1
Cow
receptor accessory protein 1
Publication Statistics
PubMed Score 42.85
PubMed score by year
PubTator Score 37.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title