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Tbio
RECQL5
ATP-dependent DNA helicase Q5

Protein Summary
Description
Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317905
  • ENSP00000317636
  • ENSG00000108469
  • ENST00000340830
  • ENSP00000341983
  • ENST00000420326
  • ENSP00000414933
  • ENST00000423245
  • ENSP00000394820
  • ENST00000584999
  • ENSP00000462248

Symbol
  • RECQ5
  • RECQ5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
histone modification site profile
0.89
kinase perturbation
0.88
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.57   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.57   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.99999996
p_ni:  3.9e-8
p_wrong:  1e-9
Score:  0.835
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999999948
p_ni:  5.1e-8
p_wrong:  1e-9
Score:  0.618
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999999574
p_ni:  6.7e-8
p_wrong:  3.6e-7
Data Source:  BioPlex
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999998402
p_ni:  0.000001589
p_wrong:  9e-9
Score:  0.858
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999995024
p_ni:  0.000004974
p_wrong:  2e-9
Score:  0.855
Data Source:  BioPlex,STRINGDB
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
p_int:  0.999970173
p_ni:  0.000029811
p_wrong:  1.7e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999922341
p_ni:  0.000077658
Score:  0.827
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.987226043
p_ni:  0.012764962
p_wrong:  0.000008995
Score:  0.69
Data Source:  BioPlex,STRINGDB
PITHD1
Tdark
Novelty:  0.32046117
p_int:  0.767124239
p_ni:  0.177207493
p_wrong:  0.055668267
Score:  0.228
Data Source:  BioPlex,STRINGDB
KIN
Tbio
Novelty:  0.01425955
Score:  0.899
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
DNA IR-damage and cellular response via ATR
WikiPathways
DNA IR-damage and cellular response via ATR
WikiPathways
DNA IR-damage and cellular response via ATR
WikiPathways
DNA IR-damage and cellular response via ATR
WikiPathways
Gastric Cancer Network 2
Name
Explore in Pharos
Explore in Source
DNA IR-damage and cellular response via ATR
DNA IR-damage and cellular response via ATR
DNA IR-damage and cellular response via ATR
DNA IR-damage and cellular response via ATR
Gastric Cancer Network 2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
58.4
forced expiratory volume
1
1
1
58.4
heel bone mineral density
1
1
1
38.8
leukocyte count
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
58.4
forced expiratory volume
1
58.4
heel bone mineral density
1
38.8
leukocyte count
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RecQ like helicase 5
VGNC:9560
454885
Macaque
RecQ like helicase 5
702951
Mouse
MGI:2156841
170472
Rat
RGD:1310823
287834
Dog
RecQ like helicase 5
VGNC:45459
483317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RecQ like helicase 5
Macaque
RecQ like helicase 5
Mouse
Rat
Dog
RecQ like helicase 5
Publication Statistics
PubMed Score 69.57
PubMed score by year
PubTator Score 51.98
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title