Tbio RECQL5 ATP-dependent DNA helicase Q5

Protein Summary

Description

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• O94762
• Q6P4G0
• Q9H0B1
• Q9P1W7
• Q9UNC8

Gene Name

• RECQL5

Ensembl ID

• ENST00000317905
• ENSP00000317636
• ENSG00000108469
• ENST00000340830
• ENSP00000341983
• ENST00000420326
• ENSP00000414933
• ENST00000423245
• ENSP00000394820
• ENST00000584999
• ENSP00000462248

Symbol

• RECQ5
• RECQ5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.97
histone modification site profile	0.89
kinase perturbation	0.88
cellular component	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q5

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atp-dependent Dna Helicase Q5

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.2   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.2   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0