Tbio RECQL5 ATP-dependent DNA helicase Q5

Protein Summary

Description

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• O94762
• Q6P4G0
• Q9H0B1
• Q9P1W7
• Q9UNC8

Gene Name

• RECQL5

Ensembl ID

• ENST00000317905
• ENSP00000317636
• ENSG00000108469
• ENST00000340830
• ENSP00000341983
• ENST00000420326
• ENSP00000414933
• ENST00000423245
• ENSP00000394820
• ENST00000584999
• ENSP00000462248

Symbol

• RECQ5
• RECQ5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.97
histone modification site profile	0.89
kinase perturbation	0.88
cellular component	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q5

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atp-dependent Dna Helicase Q5

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.57   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.57   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (127)

Explore Interacting Targets

1 – 10 of 127

• See Interactions on String-DB

POLR2G

Tbio

Family:  Enzyme

Novelty:  0.01235379

p_int:  0.99999996

p_ni:  3.9e-8

p_wrong:  1e-9

Score:  0.835

Data Source:  BioPlex,STRINGDB

LMO2

Tbio

Novelty:  0.0038279

p_int:  0.999999948

p_ni:  5.1e-8

p_wrong:  1e-9

Score:  0.618

Data Source:  BioPlex,STRINGDB

POLR2J

Tbio

Family:  Enzyme

Novelty:  0.02344868

p_int:  0.999999574

p_ni:  6.7e-8

p_wrong:  3.6e-7

Data Source:  BioPlex

RPRD1B

Tbio

Novelty:  0.0444394

p_int:  0.999998402

p_ni:  0.000001589

p_wrong:  9e-9

Score:  0.858

Data Source:  BioPlex,STRINGDB

Q6EEV4

Tbio

Family:  Enzyme

Novelty:  0.11413088

p_int:  0.999995024

p_ni:  0.000004974

p_wrong:  2e-9

Score:  0.855

Data Source:  BioPlex,STRINGDB

DXO

Tbio

Family:  Enzyme

Novelty:  0.08260087

p_int:  0.999970173

p_ni:  0.000029811

p_wrong:  1.7e-8

Score:  0.825

Data Source:  BioPlex,STRINGDB

POLR2D

Tdark

Family:  Enzyme

Novelty:  0.11021614

p_int:  0.999922341

p_ni:  0.000077658

Score:  0.827

Data Source:  BioPlex,STRINGDB

POLR2E

Tbio

Family:  Enzyme

Novelty:  0.01817288

p_int:  0.987226043

p_ni:  0.012764962

p_wrong:  0.000008995

Score:  0.69

Data Source:  BioPlex,STRINGDB

PITHD1

Tdark

Novelty:  0.32046117

p_int:  0.767124239

p_ni:  0.177207493

p_wrong:  0.055668267

Score:  0.228

Data Source:  BioPlex,STRINGDB

KIN

Tbio

Novelty:  0.01425955

Score:  0.899

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

WikiPathways (13)

Find Similar Targets

Items per page:

5

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
WikiPathways	DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
WikiPathways	DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
WikiPathways	DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
WikiPathways	Gastric Cancer Network 2	103 targets	WP2363_r105606

Name	Explore in Pharos	Explore in Source
DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
DNA IR-damage and cellular response via ATR	219 targets	WP4016_r101923
Gastric Cancer Network 2	103 targets	WP2363_r105606

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (7)

Components (6)

Processes (16)

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10

1 – 7 of 7

GO Term	Evidence	Assigned by
DNA helicase activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II complex binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATP-dependent 3'-5' DNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
four-way junction helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1	1	1		58.4
forced expiratory volume	EFO_0004314	1	1	1		58.4
heel bone mineral density	EFO_0009270	1	1	1		38.8
leukocyte count	EFO_0004308	1	1	1		36.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1		58.4
forced expiratory volume	EFO_0004314	1		58.4
heel bone mineral density	EFO_0009270	1		38.8
leukocyte count	EFO_0004308	1		36.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
DNA damage
DNA repair
DNA replication

GWAS Trait Find Similar Targets

No Header	No Header
forced expiratory volume
heel bone mineral density
leukocyte count
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RecQ like helicase 5	VGNC:9560	454885
Macaque	RecQ like helicase 5		702951
Mouse	RecQ protein-like 5	MGI:2156841	170472
Rat	RecQ like helicase 5	RGD:1310823	287834
Dog	RecQ like helicase 5	VGNC:45459	483317

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RecQ like helicase 5
Macaque	RecQ like helicase 5
Mouse	RecQ protein-like 5
Rat	RecQ like helicase 5
Dog	RecQ like helicase 5

Publication Statistics

PubMed Score 69.57

PubMed score by year

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PubTator Score 51.98

PubTator score by year

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Related Publications

Text Mined References (51)

GeneRif Annotations (38)

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PMID	Year	Title