RECQL4
ATP-dependent DNA helicase Q4
Protein Summary
DNA-dependent ATPase. May modulate chromosome segregation. The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]
- ENST00000617875
- ENSP00000482313
- ENSG00000160957
- RECQ4
- RECQ4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
protein domain | 0.92 | ||
phenotype | 0.83 | ||
biological term | 0.68 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.61 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 190.61 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.997796652
p_ni: 0.002203348
Data Source: BioPlex
KCTD17
Novelty: 0.12105733
p_int: 0.957303196
p_ni: 0.042696528
p_wrong: 2.76e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
NLGN3
Family: Enzyme
Novelty: 0.00819625
p_int: 0.953498664
p_ni: 0.046501336
p_wrong: 1e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
NEUROG3
Family: TF
Novelty: 0.00341077
p_int: 0.924007685
p_ni: 0.075992313
p_wrong: 2e-9
Data Source: BioPlex
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.918984163
p_ni: 0.081015817
p_wrong: 2e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
RNH1
Family: Enzyme
Novelty: 0.00307468
p_int: 0.885201024
p_ni: 0.114798976
p_wrong: 1e-9
Data Source: BioPlex
LZTS2
Novelty: 0.09515452
p_int: 0.868328247
p_ni: 0.131671736
p_wrong: 1.7e-8
Score: 0.172
Data Source: BioPlex,STRINGDB
CHCHD2
Novelty: 0.01615338
p_int: 0.853493117
p_ni: 0.146506883
Score: 0.19
Data Source: BioPlex,STRINGDB
ARHGAP25
Family: Enzyme
Novelty: 0.14944305
p_int: 0.851514791
p_ni: 0.14848414
p_wrong: 0.000001068
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (10)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 4 | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 90.7 | |||||
self reported educational attainment | 5 | 3 | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 2 | 2 | 83 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 90.7 | |||||
self reported educational attainment | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 83 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1931028 | 79456 | ||||||
Rat | RGD:1307732 | 300057 | ||||||
Horse | RecQ like helicase 4 | VGNC:22287 | 100064627 | |||||
Cow | RecQ like helicase 4 | VGNC:33849 | 515472 | |||||
Pig | RecQ like helicase 4 | 100524433 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Horse | RecQ like helicase 4 | |||||
Cow | RecQ like helicase 4 | |||||
Pig | RecQ like helicase 4 | |||||
Publication Statistics
PubMed Score 190.61
PubMed score by year
PubTator Score 131.13
PubTator score by year
Related Publications
Text Mined References (84)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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