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Tbio
RECQL
ATP-dependent DNA helicase Q1

Protein Summary
Description
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421138
  • ENSP00000395449
  • ENSG00000004700
  • ENST00000444129
  • ENSP00000416739

Symbol
  • RECQ1
  • RECQL1
  • RecQ1
  • RECQL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.95
protein domain
0.92
histone modification site profile
0.87
interacting protein
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.38   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.38   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.99999763
p_ni:  0.00000237
Score:  0.17
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.999987991
p_ni:  0.000011999
p_wrong:  1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.999435917
p_ni:  0.000554988
p_wrong:  0.000009095
Score:  0.163
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.99942461
p_ni:  0.000223723
p_wrong:  0.000351667
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.998917946
p_ni:  0.000536098
p_wrong:  0.000545956
Score:  0.179
Data Source:  BioPlex,STRINGDB
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.924734079
p_ni:  0.001654903
p_wrong:  0.073611019
Data Source:  BioPlex
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.982
Data Source:  STRINGDB
MSH2
Tbio
Novelty:  0.00054283
Score:  0.938
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.883
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.845
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
7
13
94.3
serum gamma-glutamyl transferase measurement
1
1
1
72.3
hemoglobin measurement
2
2
2
66.6
mean platelet volume
2
2
2
60.8
C-reactive protein measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
13
94.3
serum gamma-glutamyl transferase measurement
1
72.3
hemoglobin measurement
2
66.6
mean platelet volume
2
60.8
C-reactive protein measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RecQ like helicase
VGNC:8525
465334
Macaque
RecQ like helicase
705871
Mouse
MGI:103021
19691
Rat
RGD:1311071
312824
Dog
RecQ like helicase
VGNC:45458
486641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RecQ like helicase
Macaque
RecQ like helicase
Mouse
Rat
Dog
RecQ like helicase
Publication Statistics
PubMed Score 125.38
PubMed score by year
PubTator Score 81.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title