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Tbio
RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

Protein Summary
Description
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). The protein enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377966
  • ENSP00000367202
  • ENSG00000122707

Symbol
  • ST15
  • ST15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.84
transcription factor perturbation
0.74
biological term
0.73
gene perturbation
0.69
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.32   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.32   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
MCCC2
Tbio
Family:  Enzyme
Novelty:  0.06681335
p_int:  0.998001699
p_ni:  0.001998301
Score:  0.485
Data Source:  BioPlex,STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.980765389
p_ni:  0.01923461
p_wrong:  1e-9
Score:  0.325
Data Source:  BioPlex,STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.92670414
p_ni:  0.073295859
Score:  0.235
Data Source:  BioPlex,STRINGDB
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.975
Data Source:  STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
Score:  0.964
Data Source:  STRINGDB
TEX101
Tbio
Novelty:  0.03488625
Score:  0.918
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.904
Data Source:  STRINGDB
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.904
Data Source:  STRINGDB
MELTF
Tbio
Novelty:  0.00853228
Score:  0.904
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
0
1.2
6.8
creatine measurement
2
1
0
1.2
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
1.2
6.8
creatine measurement
0
1.2
6.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reversion inducing cysteine rich protein with kazal motifs
VGNC:9217
465092
Macaque
reversion inducing cysteine rich protein with kazal motifs
694043
Mouse
MGI:1855698
53614
Rat
RGD:1308845
313488
Dog
reversion inducing cysteine rich protein with kazal motifs
VGNC:45457
403477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reversion inducing cysteine rich protein with kazal motifs
Macaque
reversion inducing cysteine rich protein with kazal motifs
Mouse
Rat
Dog
reversion inducing cysteine rich protein with kazal motifs
Publication Statistics
PubMed Score 299.32
PubMed score by year
PubTator Score 171.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title