You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
REC8
Meiotic recombination protein REC8 homolog

Protein Summary
Description
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611366
  • ENSP00000482439
  • ENSG00000100918
  • ENST00000620473
  • ENSP00000482546
  • ENST00000642486
  • ENSP00000493523
  • ENSG00000285007
  • ENST00000646765
  • ENSP00000495458

Symbol
  • REC8L1
  • Rec8p
  • REC8L1
  • HR21spB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
transcription factor
0.64
cellular component
0.59
cell line
0.56
small molecule perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (208)
USP13
Tchem
Family:  Enzyme
Novelty:  0.03470844
p_int:  0.999999115
p_ni:  8.5e-7
p_wrong:  3.5e-8
Data Source:  BioPlex
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.999952424
p_ni:  0.000047576
Data Source:  BioPlex
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999949845
p_ni:  0.000050155
Score:  0.306
Data Source:  BioPlex,STRINGDB
SMC3
Tbio
Novelty:  0.00474377
p_int:  0.999497048
p_ni:  0.000502952
Score:  0.998
Data Source:  BioPlex,STRINGDB
SMC1A
Tchem
Novelty:  0.00898427
p_int:  0.999143923
p_ni:  0.000856077
Score:  0.983
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.99815885
p_ni:  0.000358604
p_wrong:  0.001482546
Data Source:  BioPlex
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.99805711
p_ni:  0.00194289
Score:  0.192
Data Source:  BioPlex,STRINGDB
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.971654512
p_ni:  0.028345106
p_wrong:  3.82e-7
Score:  0.945
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.958512764
p_ni:  0.041487236
Data Source:  BioPlex
STAG2
Tbio
Novelty:  0.00430441
p_int:  0.941043027
p_ni:  0.058956906
p_wrong:  6.7e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1929645
56739
Rat
RGD:1309376
290227
Dog
REC8 meiotic recombination protein
VGNC:45456
490622
Horse
REC8 meiotic recombination protein
VGNC:22284
100054815
Cow
REC8 meiotic recombination protein
VGNC:33846
516291
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
REC8 meiotic recombination protein
Horse
REC8 meiotic recombination protein
Cow
REC8 meiotic recombination protein
Publication Statistics
PubMed Score 149.27
PubMed score by year
PubTator Score 33.69
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title