You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RDM1
RAD52 motif-containing protein 1

Protein Summary
Description
May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611538
  • ENSP00000478597
  • ENSG00000276432
  • ENST00000612980
  • ENSP00000483387
  • ENSG00000278023
  • ENST00000613308
  • ENSP00000482288
  • ENST00000613554
  • ENSP00000481726
  • ENST00000615024
  • ENSP00000481648
  • ENST00000615288
  • ENSP00000477869
  • ENST00000615378
  • ENSP00000480131
  • ENST00000616596
  • ENSP00000478915
  • ENST00000616735
  • ENSP00000483566
  • ENST00000617591
  • ENSP00000479622
  • ENST00000618461
  • ENSP00000481061
  • ENST00000618511
  • ENSP00000477995
  • ENST00000619193
  • ENSP00000482981
  • ENST00000619262
  • ENSP00000479310
  • ENST00000619368
  • ENSP00000478131
  • ENST00000619828
  • ENSP00000483933
  • ENST00000620284
  • ENSP00000483549
  • ENST00000632131
  • ENSP00000487602
  • ENST00000632857
  • ENSP00000488876
  • ENST00000632922
  • ENSP00000488806
  • ENST00000632931
  • ENSP00000487935
  • ENST00000633122
  • ENSP00000488617
  • ENST00000633612
  • ENSP00000488160
  • ENST00000633984
  • ENSP00000488583
  • ENST00000634031
  • ENSP00000487863
  • ENST00000634177
  • ENSP00000487670
  • ENST00000639942
  • ENSP00000491541

Symbol
  • RAD52B
  • RAD52B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.8
kinase perturbation
0.76
transcription factor
0.64
cellular component
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0