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Tbio
RDH8
Retinol dehydrogenase 8

Protein Summary
Description
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000171214
  • ENSP00000171214
  • ENSG00000080511

Symbol
  • PRRDH
  • SDR28C2
  • PRRDH
  • SDR28C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.57
biological process
0.49
cell line
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.95
Data Source:  STRINGDB
RBP1
Tbio
Novelty:  0.00199929
Score:  0.942
Data Source:  STRINGDB
RBP2
Tbio
Novelty:  0.00823654
Score:  0.937
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.929
Data Source:  STRINGDB
RBP5
Tbio
Novelty:  0.06648663
Score:  0.929
Data Source:  STRINGDB
BCO1
Tbio
Family:  Enzyme
Novelty:  0.00784197
Score:  0.927
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.925
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.906
Data Source:  STRINGDB
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
Score:  0.9
Data Source:  STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.813
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (12)
G alpha (i) signalling events (R-HSA-418594)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
The canonical retinoid cycle in rods (twilight vision)
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
The canonical retinoid cycle in rods (twilight vision)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
48.5
1
1
0
1.3
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
49.5
apolipoprotein B measurement
1
48.5
0
1.3
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
retinol dehydrogenase 8 (all-trans)
711496
Mouse
MGI:2685028
235033
Rat
RGD:1589829
690953
Dog
retinol dehydrogenase 8
VGNC:52600
611300
Horse
retinol dehydrogenase 8
VGNC:52429
100058589
Species
Name
OMA
EggNOG
Inparanoid
Macaque
retinol dehydrogenase 8 (all-trans)
Mouse
Rat
Dog
retinol dehydrogenase 8
Horse
retinol dehydrogenase 8
Publication Statistics
PubMed Score 17.70
PubMed score by year
PubTator Score 5.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title