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Tbio
RDH16
Retinol dehydrogenase 16

Protein Summary
Description
Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398138
  • ENSP00000381206
  • ENSG00000139547

Symbol
  • RODH4
  • SDR9C8
  • RODH-4
  • SDR9C8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.78
tissue sample
0.63
gene perturbation
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.953
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.949
Data Source:  STRINGDB
RBP1
Tbio
Novelty:  0.00199929
Score:  0.948
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.943
Data Source:  STRINGDB
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
Score:  0.932
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.93
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.926
Data Source:  STRINGDB
BCO1
Tbio
Family:  Enzyme
Novelty:  0.00784197
Score:  0.921
Data Source:  STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.919
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
RA biosynthesis pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
3
52.7
red blood cell distribution width
2
2
2
50.5
1
1
0
1.1
32.6
high density lipoprotein cholesterol measurement
1
1
1
30.2
depressive symptom measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
52.7
red blood cell distribution width
2
50.5
0
1.1
32.6
high density lipoprotein cholesterol measurement
1
30.2
depressive symptom measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 16
VGNC:52074
467206
Macaque
retinol dehydrogenase 16-like
713738
Mouse
MGI:2143528
103142
Mouse
MGI:1860517
54150
Rat
RGD:735050
299511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 16
Macaque
retinol dehydrogenase 16-like
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 12.28
PubMed score by year
PubTator Score 8.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title