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Tdark
RDH14
Retinol dehydrogenase 14

Protein Summary
Description
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381249
  • ENSP00000370648
  • ENSG00000240857

Symbol
  • PAN2
  • SDR7C4
  • PAN2
  • SDR7C4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.8
kinase perturbation
0.76
tissue sample
0.72
pathway
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.999994152
p_ni:  0.000005848
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999990301
p_ni:  0.000009699
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.999976073
p_ni:  0.000023927
Data Source:  BioPlex
BRINP2
Tdark
Novelty:  0.5101917
p_int:  0.999944755
p_ni:  0.000055244
p_wrong:  1e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.999712521
p_ni:  0.000239164
p_wrong:  0.000048315
Data Source:  BioPlex
RNF170
Tbio
Family:  Enzyme
Novelty:  0.1117879
p_int:  0.999572124
p_ni:  0.000354571
p_wrong:  0.000073305
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999422328
p_ni:  0.00057742
p_wrong:  2.52e-7
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.998135042
p_ni:  0.000721267
p_wrong:  0.00114369
Score:  0.227
Data Source:  BioPlex,STRINGDB
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.9952214
p_ni:  0.004018782
p_wrong:  0.000759818
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.993268043
p_ni:  0.006261569
p_wrong:  0.000470388
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
6
5
6.1
89
2
2
2
38.7
urate measurement
2
2
2
34.8
vital capacity
1
1
1
15.7
forced expiratory volume
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
6.1
89
2
38.7
urate measurement
2
34.8
vital capacity
1
15.7
forced expiratory volume
1
15.6
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920402
105014
Rat
RGD:1565196
500629
Dog
retinol dehydrogenase 14
VGNC:49225
100856223
Cow
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
505949
Opossum
retinol dehydrogenase 14
103093572
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
retinol dehydrogenase 14
Cow
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
Opossum
retinol dehydrogenase 14
Publication Statistics
PubMed Score 2.34
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title