Protein Summary
Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
- ENST00000226193
- ENSP00000226193
- ENSG00000109047
- RCV1
- RCV1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.67 | ||
protein domain | 0.58 | ||
tissue sample | 0.54 | ||
cell type or tissue | 0.53 | ||
disease | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 379.86 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 453 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 379.86 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 453 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (136)
SCRN3
Family: Enzyme
Novelty: 0.03516382
p_int: 0.999757149
p_ni: 0.000005649
p_wrong: 0.000237202
Score: 0.287
Data Source: BioPlex,STRINGDB
RAB9A
Family: Enzyme
Novelty: 0.07006531
p_int: 0.984856209
p_ni: 0.015143785
p_wrong: 6e-9
Score: 0.256
Data Source: BioPlex,STRINGDB
HIKESHI
Novelty: 0.0683189
p_int: 0.973844022
p_ni: 0.026155969
p_wrong: 9e-9
Score: 0.332
Data Source: BioPlex,STRINGDB
ASF1B
Novelty: 0.05716701
p_int: 0.792415561
p_ni: 0.207584439
Score: 0.199
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (9)
Reactome (7)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Inactivation, recovery and regulation of the phototransduction cascade | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 3 | 1 | 3 | 62.5 | |||||
ferritin measurement | 1 | 1 | 1 | 59.9 | |||||
4 | 4 | 2 | 1.1 | 52.4 | |||||
glucose-dependent insulinotropic peptide measurement | 1 | 1 | 1 | 35 | |||||
glucose tolerance test | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 3 | 62.5 | |||||
ferritin measurement | 1 | 59.9 | |||||
2 | 1.1 | 52.4 | |||||
glucose-dependent insulinotropic peptide measurement | 1 | 35 | |||||
glucose tolerance test | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | recoverin | VGNC:9559 | 455078 | |||||
Mouse | MGI:97883 | 19674 | ||||||
Rat | RGD:620258 | 140936 | ||||||
Dog | recoverin | VGNC:45450 | 489500 | |||||
Horse | recoverin | VGNC:22277 | 100073079 | |||||
Publication Statistics
PubMed Score 379.86
PubMed score by year
PubTator Score 229.62
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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