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Tbio
RCVRN
Recoverin

Protein Summary
Description
Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226193
  • ENSP00000226193
  • ENSG00000109047

Symbol
  • RCV1
  • RCV1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
protein domain
0.58
tissue sample
0.54
cell type or tissue
0.53
disease
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.86   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 453   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.86   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
SCRN3
Tbio
Family:  Enzyme
Novelty:  0.03516382
p_int:  0.999757149
p_ni:  0.000005649
p_wrong:  0.000237202
Score:  0.287
Data Source:  BioPlex,STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.984856209
p_ni:  0.015143785
p_wrong:  6e-9
Score:  0.256
Data Source:  BioPlex,STRINGDB
HIKESHI
Tbio
Novelty:  0.0683189
p_int:  0.973844022
p_ni:  0.026155969
p_wrong:  9e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.792415561
p_ni:  0.207584439
Score:  0.199
Data Source:  BioPlex,STRINGDB
GRK1
Tchem
Family:  Kinase
Novelty:  0.00598725
Score:  0.998
Data Source:  Reactome,STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.991
Data Source:  STRINGDB
GRK7
Tchem
Family:  Kinase
Novelty:  0.01119521
Score:  0.982
Data Source:  STRINGDB
SAG
Tbio
Novelty:  0.00040944
Score:  0.97
Data Source:  STRINGDB
RBP3
Tbio
Family:  Enzyme
Novelty:  0.00204835
Score:  0.943
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.81
Data Source:  STRINGDB
Pathways (9)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
1
3
62.5
ferritin measurement
1
1
1
59.9
4
4
2
1.1
52.4
glucose-dependent insulinotropic peptide measurement
1
1
1
35
glucose tolerance test
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
62.5
ferritin measurement
1
59.9
2
1.1
52.4
glucose-dependent insulinotropic peptide measurement
1
35
glucose tolerance test
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
recoverin
VGNC:9559
455078
Mouse
MGI:97883
19674
Rat
RGD:620258
140936
Dog
recoverin
VGNC:45450
489500
Horse
recoverin
VGNC:22277
100073079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
recoverin
Mouse
Rat
Dog
recoverin
Horse
recoverin
Publication Statistics
PubMed Score 379.86
PubMed score by year
PubTator Score 229.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title