Tbio RCVRN Recoverin

Protein Summary

Description

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35243
• Q53XL0

Gene Name

• RCVRN

Ensembl ID

• ENST00000226193
• ENSP00000226193
• ENSG00000109047

Symbol

• RCV1
• RCV1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.67
protein domain	0.58
tissue sample	0.54
cell type or tissue	0.53
disease	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.21   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 453   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.21   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0