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Tbio
RCSD1
CapZ-interacting protein

Protein Summary
Description
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367854
  • ENSP00000356828
  • ENSG00000198771

Symbol
  • CAPZIP
  • MK2S4
  • CAPZIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
histone modification site profile
0.64
transcription factor binding site profile
0.64
disease perturbation
0.62
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999995129
p_ni:  0.000004871
Score:  0.722
Data Source:  BioPlex,STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
p_int:  0.999748504
p_ni:  0.000251496
Score:  0.86
Data Source:  BioPlex,STRINGDB
CAPZA1
Tbio
Novelty:  0.03448517
p_int:  0.998908883
p_ni:  0.001091117
Score:  0.959
Data Source:  BioPlex,STRINGDB
TMOD4
Tbio
Novelty:  0.00932697
Score:  0.8
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.793
Data Source:  STRINGDB
MAPKAPK3
Tchem
Family:  Kinase
Novelty:  0.02469147
Score:  0.741
Data Source:  STRINGDB
MAPKAPK2
Tchem
Family:  Kinase
Novelty:  0.00486452
Score:  0.731
Data Source:  STRINGDB
MAPK13
Tchem
Family:  Kinase
Novelty:  0.01071621
Score:  0.719
Data Source:  STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
Score:  0.696
Data Source:  STRINGDB
ARHGAP25
Tbio
Family:  Enzyme
Novelty:  0.14944305
Score:  0.696
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
70.5
myeloid white cell count
1
1
1
69.2
neutrophil count
2
1
2
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
70.5
myeloid white cell count
1
69.2
neutrophil count
2
67.9
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RCSD domain containing 1
VGNC:1488
457489
Macaque
RCSD domain containing 1
701239
Mouse
MGI:2676394
226594
Rat
RGD:1304715
360872
Dog
RCSD domain containing 1
VGNC:45449
100856164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RCSD domain containing 1
Macaque
RCSD domain containing 1
Mouse
Rat
Dog
RCSD domain containing 1
Publication Statistics
PubMed Score 8.48
PubMed score by year
PubTator Score 6.35
PubTator score by year
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Related Publications
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PMID
Year
Title