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Tdark
RCOR3
REST corepressor 3

Protein Summary
Description
May act as a component of a corepressor complex that represses transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367005
  • ENSP00000355972
  • ENSG00000117625
  • ENST00000367006
  • ENSP00000355973
  • ENST00000419091
  • ENSP00000413929
  • ENST00000452621
  • ENSP00000398558

Symbol
  • KIAA1343
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.91
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.75
cell type or tissue
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999991787
p_ni:  0.000008213
Score:  0.86
Data Source:  BioPlex,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.99981279
p_ni:  0.00018721
Score:  0.888
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999341363
p_ni:  0.000658637
Score:  0.663
Data Source:  BioPlex,STRINGDB
ZSCAN5A
Tdark
Family:  TF
Novelty:  2.15267128
p_int:  0.997545856
p_ni:  0.002454144
Score:  0.161
Data Source:  BioPlex,STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
p_int:  0.996467714
p_ni:  0.003532286
Score:  0.781
Data Source:  BioPlex,STRINGDB
ECE2
Tchem
Family:  Enzyme
Novelty:  0.03234301
p_int:  0.996305947
p_ni:  0.003694053
Score:  0.211
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.995993218
p_ni:  0.004006782
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.995518744
p_ni:  0.004481256
Score:  0.272
Data Source:  BioPlex,STRINGDB
PDGFRL
Tbio
Novelty:  0.0709225
p_int:  0.990142485
p_ni:  0.009857515
Data Source:  BioPlex
DCAF12L2
Tdark
Novelty:  2.92107204
p_int:  0.987174926
p_ni:  0.012825074
Score:  0.208
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
1
5.6
49.1
platelet crit
1
1
1
35
mean reticulocyte volume
1
1
1
34.9
mean corpuscular volume
1
1
1
29.8
household income
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
5.6
49.1
platelet crit
1
35
mean reticulocyte volume
1
34.9
mean corpuscular volume
1
29.8
household income
1
11.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
REST corepressor 3
VGNC:1487
457710
Macaque
REST corepressor 3
712037
Mouse
MGI:2441920
214742
Rat
RGD:1593864
684192
Dog
REST corepressor 3
VGNC:45448
480018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
REST corepressor 3
Macaque
REST corepressor 3
Mouse
Rat
Dog
REST corepressor 3
Publication Statistics
PubMed Score 3.94
PubMed score by year
PubTator Score 1.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title