Tdark RCOR3 REST corepressor 3

Protein Summary

Description

May act as a component of a corepressor complex that represses transcription.

Uniprot Accession IDs

• Q9P2K3
• B3KYA2
• B4DYY7
• Q5VT47
• Q7L9I5
• Q8N5U3
• Q9NV83

Gene Name

• RCOR3

Ensembl ID

• ENST00000367005
• ENSP00000355972
• ENSG00000117625
• ENST00000367006
• ENSP00000355973
• ENST00000419091
• ENSP00000413929
• ENST00000452621
• ENSP00000398558

Symbol

• KIAA1343

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
histone modification site profile	0.91
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.75
cell type or tissue	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

• See Interactions on String-DB

HMG20A

Tbio

Family:  TF

Novelty:  0.11994252

p_int:  0.999991787

p_ni:  0.000008213

Score:  0.86

Data Source:  BioPlex,STRINGDB

HMG20B

Tbio

Family:  TF

Novelty:  0.05983143

p_int:  0.99981279

p_ni:  0.00018721

Score:  0.888

Data Source:  BioPlex,STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.999341363

p_ni:  0.000658637

Score:  0.663

Data Source:  BioPlex,STRINGDB

ZSCAN5A

Tdark

Family:  TF

Novelty:  2.15267128

p_int:  0.997545856

p_ni:  0.002454144

Score:  0.161

Data Source:  BioPlex,STRINGDB

SNAI1

Tbio

Family:  TF

Novelty:  0.00040495

p_int:  0.996467714

p_ni:  0.003532286

Score:  0.781

Data Source:  BioPlex,STRINGDB

ECE2

Tchem

Family:  Enzyme

Novelty:  0.03234301

p_int:  0.996305947

p_ni:  0.003694053

Score:  0.211

Data Source:  BioPlex,STRINGDB

CRYAA

Tchem

Novelty:  0.01914081

p_int:  0.995993218

p_ni:  0.004006782

Data Source:  BioPlex

CTBP1

Tbio

Novelty:  0.00243818

p_int:  0.995518744

p_ni:  0.004481256

Score:  0.272

Data Source:  BioPlex,STRINGDB

PDGFRL

Tbio

Novelty:  0.0709225

p_int:  0.990142485

p_ni:  0.009857515

Data Source:  BioPlex

DCAF12L2

Tdark

Novelty:  2.92107204

p_int:  0.987174926

p_ni:  0.012825074

Score:  0.208

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (5)

Components (3)

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1 – 5 of 5

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription corepressor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription factor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription regulatory region DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	2	2	1	5.6	49.1
platelet crit	EFO_0007985	1	1	1		35
mean reticulocyte volume	EFO_0010701	1	1	1		34.9
mean corpuscular volume	EFO_0004526	1	1	1		29.8
household income	EFO_0009695	1	1	1		11.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	5.6	49.1
platelet crit	EFO_0007985	1		35
mean reticulocyte volume	EFO_0010701	1		34.9
mean corpuscular volume	EFO_0004526	1		29.8
household income	EFO_0009695	1		11.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
hair color
household income
intelligence
mathematical ability
mean corpuscular volume
mean reticulocyte volume
platelet crit
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	REST corepressor 3	VGNC:1487	457710
Macaque	REST corepressor 3		712037
Mouse	REST corepressor 3	MGI:2441920	214742
Rat	REST corepressor 3	RGD:1593864	684192
Dog	REST corepressor 3	VGNC:45448	480018

Species	Name	OMA	EggNOG	Inparanoid
Chimp	REST corepressor 3
Macaque	REST corepressor 3
Mouse	REST corepressor 3
Rat	REST corepressor 3
Dog	REST corepressor 3

Publication Statistics

PubMed Score 3.94

PubMed score by year

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PubTator Score 1.38

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (2)

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PMID	Year	Title