Protein Summary
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in de ...more
- ENST00000262241
- ENSP00000262241
- ENSG00000089902
- KIAA0071
- RCOR
- RCOR
- COREST
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein complex | 0.98 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.91 | ||
biological process | 0.83 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.34 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.34 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (202)
HMG20A
Family: TF
Novelty: 0.11994252
p_int: 0.999811195
p_ni: 0.000188805
Score: 0.741
Data Source: BioPlex,STRINGDB
HMG20B
Family: TF
Novelty: 0.05983143
p_int: 0.99968536
p_ni: 0.00031464
Score: 0.993
Data Source: BioPlex,STRINGDB
HDAC1
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999416918
p_ni: 0.000583082
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
DCAF12L2
Novelty: 2.92107204
p_int: 0.993467248
p_ni: 0.006532752
Score: 0.226
Data Source: BioPlex,STRINGDB
ZSCAN5A
Family: TF
Novelty: 2.15267128
p_int: 0.990556388
p_ni: 0.009443596
p_wrong: 1.6e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
CTBP1
Novelty: 0.00243818
p_int: 0.965687315
p_ni: 0.034312685
Score: 0.779
Data Source: BioPlex,STRINGDB
ECE2
Family: Enzyme
Novelty: 0.03234301
p_int: 0.946466671
p_ni: 0.053533329
Score: 0.252
Data Source: BioPlex,STRINGDB
SNAI1
Family: TF
Novelty: 0.00040495
p_int: 0.937050558
p_ni: 0.062949442
Score: 0.997
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (10)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | HDACs deacetylate histones | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Factors involved in megakaryocyte development and platelet production | ||||
HDACs deacetylate histones | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (6)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 4 | 5 | 5 | 2.6 | 97 | ||||
serum non-albumin protein measurement | 2 | 4 | 4 | 95.2 | |||||
platelet crit | 2 | 3 | 4 | 92.3 | |||||
blood protein measurement | 2 | 3 | 3 | 89.7 | |||||
reticulocyte measurement | 2 | 3 | 3 | 87.8 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 5 | 2.6 | 97 | ||||
serum non-albumin protein measurement | 4 | 95.2 | |||||
platelet crit | 4 | 92.3 | |||||
blood protein measurement | 3 | 89.7 | |||||
reticulocyte measurement | 3 | 87.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:106340 | 217864 | ||||||
Dog | REST corepressor 1 | VGNC:45446 | 612620 | |||||
Horse | REST corepressor 1 | VGNC:22274 | 100058618 | |||||
Cow | REST corepressor 1 | VGNC:33834 | 506525 | |||||
Pig | REST corepressor 1 | 100155804 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Dog | REST corepressor 1 | |||||
Horse | REST corepressor 1 | |||||
Cow | REST corepressor 1 | |||||
Pig | REST corepressor 1 | |||||
Publication Statistics
PubMed Score 130.34
PubMed score by year
PubTator Score 64.77
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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