Tbio RCOR1 REST corepressor 1

Protein Summary

Description

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9UKL0
• J3KN32
• Q15044
• Q6P2I9
• Q86VG5

Gene Name

• RCOR1

Ensembl ID

• ENST00000262241
• ENSP00000262241
• ENSG00000089902

Symbol

• KIAA0071
• RCOR
• RCOR
• COREST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.98
kinase perturbation	0.91
transcription factor binding site profile	0.91
biological process	0.83
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.34   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.34   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (202)

Explore Interacting Targets

1 – 10 of 202

• See Interactions on String-DB

HMG20A

Tbio

Family:  TF

Novelty:  0.11994252

p_int:  0.999811195

p_ni:  0.000188805

Score:  0.741

Data Source:  BioPlex,STRINGDB

HMG20B

Tbio

Family:  TF

Novelty:  0.05983143

p_int:  0.99968536

p_ni:  0.00031464

Score:  0.993

Data Source:  BioPlex,STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.999416918

p_ni:  0.000583082

Score:  0.991

Data Source:  BioPlex,Reactome,STRINGDB

PDGFRL

Tbio

Novelty:  0.0709225

p_int:  0.994435849

p_ni:  0.005564151

Data Source:  BioPlex

DCAF12L2

Tdark

Novelty:  2.92107204

p_int:  0.993467248

p_ni:  0.006532752

Score:  0.226

Data Source:  BioPlex,STRINGDB

ZSCAN5A

Tdark

Family:  TF

Novelty:  2.15267128

p_int:  0.990556388

p_ni:  0.009443596

p_wrong:  1.6e-8

Score:  0.198

Data Source:  BioPlex,STRINGDB

CRYAA

Tchem

Novelty:  0.01914081

p_int:  0.98829254

p_ni:  0.01170746

Data Source:  BioPlex

CTBP1

Tbio

Novelty:  0.00243818

p_int:  0.965687315

p_ni:  0.034312685

Score:  0.779

Data Source:  BioPlex,STRINGDB

ECE2

Tchem

Family:  Enzyme

Novelty:  0.03234301

p_int:  0.946466671

p_ni:  0.053533329

Score:  0.252

Data Source:  BioPlex,STRINGDB

SNAI1

Tbio

Family:  TF

Novelty:  0.00040495

p_int:  0.937050558

p_ni:  0.062949442

Score:  0.997

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (10)

KEGG (1)

Chromatin modifying enzymes (R-HSA-3247509)

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5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	HDACs deacetylate histones	60 targets	R-HSA-3214815
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
HDACs deacetylate histones	60 targets	R-HSA-3214815
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (6)

Components (5)

Processes (4)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription factor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
histone deacetylase activity	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (32)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 32

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	4	5	5	2.6	97
serum non-albumin protein measurement	EFO_0004568	2	4	4		95.2
platelet crit	EFO_0007985	2	3	4		92.3
blood protein measurement	EFO_0007937	2	3	3		89.7
reticulocyte measurement	EFO_0010700	2	3	3		87.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 32

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	5	2.6	97
serum non-albumin protein measurement	EFO_0004568	4		95.2
platelet crit	EFO_0007985	4		92.3
blood protein measurement	EFO_0007937	3		89.7
reticulocyte measurement	EFO_0010700	3		87.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Chromatin regulator
Coiled coil
Complete proteome
Host-virus interaction
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
albumin:globulin ratio measurement
allergic rhinitis
allergy
apolipoprotein A 1 measurement
asthma
blood protein measurement
body height
body mass index
childhood onset asthma

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
hematopoietic system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	REST corepressor 1	MGI:106340	217864
Dog	REST corepressor 1	VGNC:45446	612620
Horse	REST corepressor 1	VGNC:22274	100058618
Cow	REST corepressor 1	VGNC:33834	506525
Pig	REST corepressor 1		100155804

Species	Name	OMA	EggNOG	Inparanoid
Mouse	REST corepressor 1
Dog	REST corepressor 1
Horse	REST corepressor 1
Cow	REST corepressor 1
Pig	REST corepressor 1

Publication Statistics

PubMed Score 130.34

PubMed score by year

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PubTator Score 64.77

PubTator score by year

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Related Publications

Text Mined References (66)

GeneRif Annotations (29)

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10

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PMID	Year	Title