Protein Summary
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
- ENST00000309657
- ENSP00000309163
- ENSG00000173653
- FACE2
- RCE1A
- RCE1B
- FACE2
- RCE1A
- RCE1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.92 | ||
histone modification site profile | 0.83 | ||
kinase perturbation | 0.71 | ||
cellular component | 0.69 | ||
cell line | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.85 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 117 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.85 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 117 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (7)
Protein-Protein Interactions (77)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Ub-specific processing proteases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Ub-specific processing proteases | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 3 | 5 | 91.2 | |||||
BMI-adjusted waist circumference | 2 | 2 | 4 | 90.3 | |||||
waist circumference | 1 | 1 | 1 | 56.2 | |||||
chronotype measurement | 1 | 1 | 1 | 48.5 | |||||
physical activity measurement | 1 | 1 | 1 | 38.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 5 | 91.2 | |||||
BMI-adjusted waist circumference | 4 | 90.3 | |||||
waist circumference | 1 | 56.2 | |||||
chronotype measurement | 1 | 48.5 | |||||
physical activity measurement | 1 | 38.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Ras converting CAAX endopeptidase 1 | VGNC:1027 | 451355 | |||||
Macaque | Ras converting CAAX endopeptidase 1 | 713224 | ||||||
Mouse | MGI:1336895 | 19671 | ||||||
Rat | RGD:1309261 | 309153 | ||||||
Dog | Ras converting CAAX endopeptidase 1 | 483705 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Ras converting CAAX endopeptidase 1 | |||||
Macaque | Ras converting CAAX endopeptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Ras converting CAAX endopeptidase 1 | |||||
Publication Statistics
PubMed Score 77.85
PubMed score by year
PubTator Score 38.85
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
|---|