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Tbio
RCCD1
RCC1 domain-containing protein 1

Protein Summary
Description
Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394258
  • ENSP00000377801
  • ENSG00000166965
  • ENST00000556618
  • ENSP00000451963
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
tissue sample
0.74
transcription factor binding site profile
0.68
cell type or tissue
0.66
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
KCTD9
Tbio
Novelty:  0.22841768
p_int:  0.999999999
p_ni:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
KDM8
Tbio
Family:  Epigenetic
Novelty:  0.03368031
p_int:  0.999999996
p_wrong:  3e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
MAPK8IP3
Tbio
Family:  Enzyme
Novelty:  0.01127812
p_int:  0.998213611
p_ni:  0.001786389
Score:  0.305
Data Source:  BioPlex,STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
p_int:  0.996573796
p_ni:  0.003426204
Score:  0.381
Data Source:  BioPlex,STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.994910894
p_ni:  0.005089106
Data Source:  BioPlex
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.994430804
p_ni:  0.005569196
Data Source:  BioPlex
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
p_int:  0.984764655
p_ni:  0.015035471
p_wrong:  0.000199874
Data Source:  BioPlex
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.977902236
p_ni:  0.000489565
p_wrong:  0.021608198
Score:  0.169
Data Source:  BioPlex,STRINGDB
C5orf34
Tdark
Novelty:  1.01063928
p_int:  0.972807099
p_ni:  0.027115462
p_wrong:  0.000077439
Data Source:  BioPlex
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.969715465
p_ni:  0.030284535
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
6
7
99.5
8
7
4
1.1
96.3
9
5
4
1.1
95.1
mean platelet volume
3
2
3
93.3
3
3
0
1.1
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
99.5
4
1.1
96.3
4
1.1
95.1
mean platelet volume
3
93.3
0
1.1
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RCC1 domain containing 1
VGNC:1892
467764
Macaque
RCC1 domain containing 1
715524
Mouse
MGI:2444156
269955
Rat
RGD:1309901
308760
Dog
RCC1 domain containing 1
VGNC:45442
100683536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RCC1 domain containing 1
Macaque
RCC1 domain containing 1
Mouse
Rat
Dog
RCC1 domain containing 1
Publication Statistics
PubMed Score 13.23
PubMed score by year
PubTator Score 4.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title