Tbio RCBTB2 RCC1 and BTB domain-containing protein 2

Protein Summary

Description

This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• O95199
• B2RDW8

Gene Name

• RCBTB2

Ensembl ID

• ENST00000344532
• ENSP00000345144
• ENSG00000136161
• ENST00000544904
• ENSP00000443904

Symbol

• CHC1L
• RLG
• RLG
• CHC1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
gene perturbation	0.73
protein domain	0.73
small molecule perturbation	0.73
histone modification site profile	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Rcc1 And Btb Domain-containing Protein 2

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rcc1 And Btb Domain-containing Protein 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Rcc1 And Btb Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.79   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.79   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0