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Tbio
RCBTB2
RCC1 and BTB domain-containing protein 2

Protein Summary
Description
This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344532
  • ENSP00000345144
  • ENSG00000136161
  • ENST00000544904
  • ENSP00000443904

Symbol
  • CHC1L
  • RLG
  • RLG
  • CHC1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
gene perturbation
0.73
protein domain
0.73
small molecule perturbation
0.73
histone modification site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.998830703
p_ni:  0.001169288
p_wrong:  9e-9
Data Source:  BioPlex
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
p_int:  0.997078248
p_ni:  0.002921749
p_wrong:  3e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.996282228
p_ni:  0.003717772
p_wrong:  1e-9
Score:  0.508
Data Source:  BioPlex,STRINGDB
RCBTB1
Tbio
Novelty:  0.12259073
p_int:  0.996007133
p_ni:  0.003992866
Score:  0.329
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.975335657
p_ni:  0.01785649
p_wrong:  0.006807853
Data Source:  BioPlex
ZBTB18
Tbio
Family:  TF
Novelty:  0.03802355
p_int:  0.974990453
p_ni:  0.025006045
p_wrong:  0.000003503
Score:  0.2
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.95813837
p_ni:  0.04186163
Score:  0.152
Data Source:  BioPlex,STRINGDB
RUNX3
Tbio
Family:  TF
Novelty:  0.00144472
p_int:  0.950063665
p_ni:  0.032400654
p_wrong:  0.017535681
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.94618045
p_ni:  0.053816837
p_wrong:  0.000002713
Data Source:  BioPlex
ZNF558
Tdark
Family:  TF
Novelty:  0.821338
p_int:  0.944975306
p_ni:  0.034361337
p_wrong:  0.020663358
Score:  0.52
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RCC1 and BTB domain containing protein 2
VGNC:7832
452716
Macaque
RCC1 and BTB domain containing protein 2
705199
Mouse
MGI:1917200
105670
Rat
RGD:735048
290363
Dog
RCC1 and BTB domain containing protein 2
VGNC:49731
485446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RCC1 and BTB domain containing protein 2
Macaque
RCC1 and BTB domain containing protein 2
Mouse
Rat
Dog
RCC1 and BTB domain containing protein 2
Publication Statistics
PubMed Score 25.50
PubMed score by year
PubTator Score 7.58
PubTator score by year
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Related Publications
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PMID
Year
Title