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Tbio
RCBTB1
RCC1 and BTB domain-containing protein 1

Protein Summary
Description
May be involved in cell cycle regulation by chromatin remodeling. This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258646
  • ENSP00000258646
  • ENSG00000136144
  • ENST00000378302
  • ENSP00000367552

Symbol
  • CLLD7
  • E4.5
  • GLP
  • CLLD7
  • CLLL7
  • RDEOA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
histone modification site profile
0.9
cell type or tissue
0.77
protein domain
0.73
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
RCBTB2
Tbio
Novelty:  0.04244536
p_int:  0.996007133
p_ni:  0.003992866
Score:  0.329
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.968848439
p_ni:  0.031151561
Score:  0.303
Data Source:  BioPlex,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.849981718
p_ni:  0.150018282
Data Source:  BioPlex
LRFN4
Tbio
Novelty:  0.12511571
Score:  0.758
Data Source:  STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
Score:  0.742
Data Source:  STRINGDB
CDADC1
Tbio
Family:  Enzyme
Novelty:  0.43344342
Score:  0.691
Data Source:  STRINGDB
LRFN3
Tdark
Novelty:  0.30018245
Score:  0.658
Data Source:  STRINGDB
TBPL1
Tbio
Novelty:  0.02184575
Score:  0.657
Data Source:  STRINGDB
SLIT1
Tbio
Novelty:  0.01255624
Score:  0.644
Data Source:  STRINGDB
SLIT3
Tbio
Novelty:  0.00465012
Score:  0.64
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
3
4
79.7
myeloid white cell count
2
2
2
78.5
monocyte count
2
2
2
78.1
refractive error
2
2
1
6.3
77.5
BMI-adjusted hip circumference
2
3
3
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
79.7
myeloid white cell count
2
78.5
monocyte count
2
78.1
refractive error
1
6.3
77.5
BMI-adjusted hip circumference
3
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RCC1 and BTB domain containing protein 1
VGNC:13134
452720
Macaque
RCC1 and BTB domain containing protein 1
706627
Mouse
MGI:1918580
71330
Rat
RGD:1308467
361050
Dog
RCC1 and BTB domain containing protein 1
VGNC:45439
485440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RCC1 and BTB domain containing protein 1
Macaque
RCC1 and BTB domain containing protein 1
Mouse
Rat
Dog
RCC1 and BTB domain containing protein 1
Publication Statistics
PubMed Score 15.30
PubMed score by year
PubTator Score 6.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title