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Tbio
RCAN3
Calcipressin-3

Protein Summary
Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374393
  • ENSP00000363514
  • ENSG00000117602
  • ENST00000374395
  • ENSP00000363516
  • ENST00000412742
  • ENSP00000391912
  • ENST00000425530
  • ENSP00000409540
  • ENST00000436717
  • ENSP00000414447
  • ENST00000538532
  • ENSP00000445401
  • ENST00000610732
  • ENSP00000479300
  • ENST00000616511
  • ENSP00000478174
  • ENST00000618490
  • ENSP00000484519
  • ENST00000630217
  • ENSP00000486836

Symbol
  • DSCR1L2
  • RCN3
  • MCIP3
  • hRCN3
  • DSCR1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.86
transcription factor perturbation
0.84
small molecule perturbation
0.65
histone modification site profile
0.64
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  1
Score:  0.873
Data Source:  BioPlex,STRINGDB
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  1
Score:  0.851
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.999999874
p_ni:  1.24e-7
p_wrong:  2e-9
Score:  0.922
Data Source:  BioPlex,STRINGDB
ARMT1
Tbio
Family:  Enzyme
Novelty:  0.19632869
p_int:  0.999997541
p_ni:  0.000002459
Score:  0.214
Data Source:  BioPlex,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
p_int:  0.999887007
p_ni:  0.000112993
Score:  0.922
Data Source:  BioPlex,STRINGDB
SMYD3
Tchem
Family:  Epigenetic
Novelty:  0.01040802
p_int:  0.9960711
p_ni:  0.003548159
p_wrong:  0.000380741
Score:  0.207
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.967655763
p_ni:  0.032344237
p_wrong:  1e-9
Score:  0.424
Data Source:  BioPlex,STRINGDB
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.900982803
p_ni:  0.099017197
Data Source:  BioPlex
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.771574602
p_ni:  0.228425385
p_wrong:  1.3e-8
Data Source:  BioPlex
TNNI3
Tbio
Novelty:  0.00020053
Score:  0.848
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RCAN family member 3
719315
Mouse
MGI:1858220
53902
Rat
RGD:1311826
362627
Dog
RCAN family member 3
VGNC:45438
487369
Horse
RCAN family member 3
VGNC:22264
100071487
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RCAN family member 3
Mouse
Rat
Dog
RCAN family member 3
Horse
RCAN family member 3
Publication Statistics
PubMed Score 9.61
PubMed score by year
PubTator Score 9.63
PubTator score by year
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Related Publications
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PMID
Year
Title