Pharos : Target Details

Tbio

Protein Summary

Description

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).

Uniprot Accession IDs

Gene Name

RCAN3

Ensembl ID

ENST00000374393
ENSP00000363514
ENSG00000117602
ENST00000374395
ENSP00000363516
ENST00000412742
ENSP00000391912
ENST00000425530
ENSP00000409540
ENST00000436717
ENSP00000414447
ENST00000538532
ENSP00000445401
ENST00000610732
ENSP00000479300
ENST00000616511
ENSP00000478174
ENST00000618490
ENSP00000484519
ENST00000630217
ENSP00000486836

Symbol

DSCR1L2
RCN3
MCIP3
hRCN3
DSCR1L2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.86

transcription factor perturbation	0.84

small molecule perturbation	0.65

histone modification site profile	0.64

disease perturbation	0.62

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61 (req: < 5)

View Publications

Gene RIFs: 8 (req: <= 3)

View Gene RIFs

Antibodies: 238 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.61 (req: >= 5)

Gene RIFs: 8 (req: > 3)

Antibodies: 238 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

See Interactions on String-DB

PPP3CA

Tchem

Family: Enzyme

Novelty: 0.00234189

p_int: 1

Score: 0.873

Data Source: BioPlex,STRINGDB

PPP3CC

Tbio

Family: Enzyme

Novelty: 0.02633046

p_int: 1

Score: 0.851

Data Source: BioPlex,STRINGDB

PPP3R1

Tbio

Novelty: 0.00263264

p_int: 0.999999874

p_ni: 1.24e-7

p_wrong: 2e-9

Score: 0.922

Data Source: BioPlex,STRINGDB

ARMT1

Tbio

Family: Enzyme

Novelty: 0.19632869

p_int: 0.999997541

p_ni: 0.000002459

Score: 0.214

Data Source: BioPlex,STRINGDB

PPP3CB

Tbio

Family: Enzyme

Novelty: 0.02156713

p_int: 0.999887007

p_ni: 0.000112993

Score: 0.922

Data Source: BioPlex,STRINGDB

SMYD3

Tchem

Family: Epigenetic

Novelty: 0.01040802

p_int: 0.9960711

p_ni: 0.003548159

p_wrong: 0.000380741

Score: 0.207

Data Source: BioPlex,STRINGDB

CDK4

Tclin

Family: Kinase

Novelty: 0.00036742

p_int: 0.967655763

p_ni: 0.032344237

p_wrong: 1e-9

Score: 0.424

Data Source: BioPlex,STRINGDB

OBSL1

Tbio

Novelty: 0.0325947

p_int: 0.900982803

p_ni: 0.099017197

Data Source: BioPlex

PLS1

Tbio

Novelty: 0.00538817

p_int: 0.771574602

p_ni: 0.228425385

p_wrong: 1.3e-8

Data Source: BioPlex

TNNI3

Tbio

Novelty: 0.00020053

Score: 0.848

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (4)

Components (1)

Processes (3)

Find Similar Targets

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB

troponin I binding	Inferred from Physical Interaction (IPI)	UniProtKB

calcium-dependent protein serine/threonine phosphatase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

RNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID
Macaque	RCAN family member 3		719315

Mouse	regulator of calcineurin 3	MGI:1858220	53902

Rat	RCAN family member 3	RGD:1311826	362627

Dog	RCAN family member 3	VGNC:45438	487369

Horse	RCAN family member 3	VGNC:22264	100071487

Species	Name	OMA	EggNOG	Inparanoid
Macaque	RCAN family member 3

Mouse	regulator of calcineurin 3

Rat	RCAN family member 3

Dog	RCAN family member 3

Horse	RCAN family member 3

Publication Statistics

PubMed Score 9.61

PubMed score by year

PubTator Score 9.63

PubTator score by year

Related Publications

Text Mined References (17)

GeneRif Annotations (8)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Alternative splicing

Complete proteome

Polymorphism

Reference proteome