Tbio RCAN2 Calcipressin-2

Protein Summary

Description

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q14206
• A6ND07
• B3KR46
• Q5VWF7
• Q5VWF8
• Q8N116

Gene Name

• RCAN2

Ensembl ID

• ENST00000306764
• ENSP00000305223
• ENSG00000172348
• ENST00000330430
• ENSP00000329454
• ENST00000371374
• ENSP00000360425

Symbol

• DSCR1L1
• ZAKI4
• CSP2
• RCN2
• MCIP2
• ZAKI4
• ZAKI-4
• DSCR1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
transcription factor perturbation	0.8
microRNA	0.71
PubMedID	0.68
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Calcipressin-2

DTO Classes

Protein / Signaling / Calcipressin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.08   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.08   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (53)

Explore Interacting Targets

1 – 10 of 53

• See Interactions on String-DB

PPP3CC

Tbio

Family:  Enzyme

Novelty:  0.02633046

p_int:  0.99998547

p_ni:  0.00001453

Score:  0.835

Data Source:  BioPlex,STRINGDB

PPP3R1

Tbio

Novelty:  0.00263264

p_int:  0.9999415

p_ni:  0.0000585

Score:  0.805

Data Source:  BioPlex,STRINGDB

PPP3CB

Tbio

Family:  Enzyme

Novelty:  0.02156713

p_int:  0.998958804

p_ni:  0.001041196

Score:  0.848

Data Source:  BioPlex,STRINGDB

PPP3CA

Tchem

Family:  Enzyme

Novelty:  0.00234189

p_int:  0.997092214

p_ni:  0.002907786

Score:  0.832

Data Source:  BioPlex,STRINGDB

AMY1A

Tchem

Family:  Enzyme

Novelty:  0.00210045

p_int:  0.98952388

p_ni:  0.01047612

Data Source:  BioPlex

GSK3A

Tclin

Family:  Kinase

Novelty:  0.00925708

p_int:  0.977566176

p_ni:  0.021533549

p_wrong:  0.000900276

Score:  0.735

Data Source:  BioPlex,STRINGDB

CRNN

Tbio

Novelty:  0.01648731

p_int:  0.976375934

p_ni:  0.023624063

p_wrong:  3e-9

Data Source:  BioPlex

CST1

Tbio

Novelty:  0.02399609

p_int:  0.970922856

p_ni:  0.02834937

p_wrong:  0.000727774

Data Source:  BioPlex

ZG16B

Tbio

Novelty:  0.08792924

p_int:  0.967385168

p_ni:  0.032614832

Data Source:  BioPlex

HSBP1

Tbio

Novelty:  0.09422832

p_int:  0.941673124

p_ni:  0.021275827

p_wrong:  0.037051049

Score:  0.158

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

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Upstream (2)

1 – 2 of 2

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Thyroid hormone signaling pathway

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Thyroid hormone signaling pathway

Pathways (4)

KEGG (1)

PathwayCommons (2)

WikiPathways (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Thyroid hormone signaling pathway	119 targets	path:hsa04919

Name	Explore in Pharos	Explore in Source
Thyroid hormone signaling pathway	119 targets	path:hsa04919

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
calcium-dependent protein serine/threonine phosphatase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	2	2	2		77.6
mean corpuscular volume	EFO_0004526	1	1	1		10.4
mean reticulocyte volume	EFO_0010701	1	1	1		10.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	2		77.6
mean corpuscular volume	EFO_0004526	1		10.4
mean reticulocyte volume	EFO_0010701	1		10.3

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UniProt Keyword Find Similar Targets

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Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
mean corpuscular volume
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
liver/biliary system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	regulator of calcineurin 2	VGNC:3680	462742
Macaque	24-hydroxycholesterol 7-alpha-hydroxylase [Source:RefSeq peptide;Acc:NP_001181799]
Mouse	regulator of calcineurin 2	MGI:1858219	53901
Rat	regulator of calcineurin 2	RGD:69198	140666
Dog	regulator of calcineurin 2	VGNC:45437	609864

Species	Name	OMA	EggNOG	Inparanoid
Chimp	regulator of calcineurin 2
Macaque	24-hydroxycholesterol 7-alpha-hydroxylase [Source:RefSeq peptide;Acc:NP_001181799]
Mouse	regulator of calcineurin 2
Rat	regulator of calcineurin 2
Dog	regulator of calcineurin 2

Publication Statistics

PubMed Score 577.08

PubMed score by year

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PubTator Score 615.05

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (5)

Items per page:

10

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PMID	Year	Title