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Tbio
RCAN2
Calcipressin-2

Protein Summary
Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306764
  • ENSP00000305223
  • ENSG00000172348
  • ENST00000330430
  • ENSP00000329454
  • ENST00000371374
  • ENSP00000360425

Symbol
  • DSCR1L1
  • ZAKI4
  • CSP2
  • RCN2
  • MCIP2
  • ZAKI4
  • ZAKI-4
  • DSCR1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
transcription factor perturbation
0.8
microRNA
0.71
PubMedID
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 577.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.99998547
p_ni:  0.00001453
Score:  0.835
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.9999415
p_ni:  0.0000585
Score:  0.805
Data Source:  BioPlex,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
p_int:  0.998958804
p_ni:  0.001041196
Score:  0.848
Data Source:  BioPlex,STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.997092214
p_ni:  0.002907786
Score:  0.832
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.98952388
p_ni:  0.01047612
Data Source:  BioPlex
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.977566176
p_ni:  0.021533549
p_wrong:  0.000900276
Score:  0.735
Data Source:  BioPlex,STRINGDB
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.976375934
p_ni:  0.023624063
p_wrong:  3e-9
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.970922856
p_ni:  0.02834937
p_wrong:  0.000727774
Data Source:  BioPlex
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.967385168
p_ni:  0.032614832
Data Source:  BioPlex
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.941673124
p_ni:  0.021275827
p_wrong:  0.037051049
Score:  0.158
Data Source:  BioPlex,STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
77.6
mean corpuscular volume
1
1
1
10.4
mean reticulocyte volume
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
77.6
mean corpuscular volume
1
10.4
mean reticulocyte volume
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of calcineurin 2
VGNC:3680
462742
Macaque
24-hydroxycholesterol 7-alpha-hydroxylase [Source:RefSeq peptide;Acc:NP_001181799]
Mouse
MGI:1858219
53901
Rat
RGD:69198
140666
Dog
regulator of calcineurin 2
VGNC:45437
609864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of calcineurin 2
Macaque
24-hydroxycholesterol 7-alpha-hydroxylase [Source:RefSeq peptide;Acc:NP_001181799]
Mouse
Rat
Dog
regulator of calcineurin 2
Publication Statistics
PubMed Score 577.08
PubMed score by year
PubTator Score 615.05
PubTator score by year
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Related Publications
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PMID
Year
Title