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Tbio
RCAN1
Calcipressin-1

Protein Summary
Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313806
  • ENSP00000320768
  • ENSG00000159200
  • ENST00000381132
  • ENSP00000370524
  • ENST00000399272
  • ENSP00000382214
  • ENST00000443408
  • ENSP00000392438
  • ENST00000482533
  • ENSP00000419624
  • ENST00000487990
  • ENSP00000419252
  • ENST00000620920
  • ENSP00000477646

Symbol
  • ADAPT78
  • CSP1
  • DSC1
  • DSCR1
  • CSP1
  • DSC1
  • RCN1
  • DSCR1
  • MCIP1
  • ADAPT78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.9
transcription factor
0.9
PubMedID
0.89
transcription factor perturbation
0.88
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.73   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 521   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.73   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  1
Score:  0.954
Data Source:  BioPlex,STRINGDB
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  1
Score:  0.827
Data Source:  BioPlex,STRINGDB
PPP3R2
Tbio
Novelty:  0.01121867
p_int:  0.999999919
p_ni:  4.9e-8
p_wrong:  3.1e-8
Score:  0.368
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.99999773
p_ni:  7.7e-7
p_wrong:  0.000001501
Score:  0.715
Data Source:  BioPlex,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
p_int:  0.999982418
p_ni:  0.000017582
Score:  0.846
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.99997993
p_ni:  0.000020069
Score:  0.885
Data Source:  BioPlex,STRINGDB
ARMT1
Tbio
Family:  Enzyme
Novelty:  0.19632869
p_int:  0.999956051
p_ni:  0.000043949
Score:  0.269
Data Source:  BioPlex,STRINGDB
SRBD1
Tbio
Novelty:  0.18931356
p_int:  0.999946791
p_ni:  0.000053205
p_wrong:  4e-9
Score:  0.694
Data Source:  BioPlex,STRINGDB
FAM122A
Tbio
Novelty:  0.3107759
p_int:  0.999875073
p_ni:  0.000014226
p_wrong:  0.000110701
Score:  0.85
Data Source:  BioPlex,STRINGDB
CST2
Tbio
Novelty:  0.02114441
p_int:  0.99884303
p_ni:  0.00079259
p_wrong:  0.00036438
Score:  0.186
Data Source:  BioPlex,STRINGDB
Pathways (44)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Oxytocin signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
KEGG
Thyroid hormone signaling pathway
Name
Explore in Pharos
Explore in Source
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Thyroid hormone signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
2
88
90.1
QT interval
5
3
3
3.1
89.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
88
90.1
QT interval
3
3.1
89.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
regulator of calcineurin 1
697108
Mouse
MGI:1890564
54720
Rat
RGD:631338
266766
Dog
regulator of calcineurin 1
VGNC:45436
607887
Horse
regulator of calcineurin 1
VGNC:22262
100062432
Species
Name
OMA
EggNOG
Inparanoid
Macaque
regulator of calcineurin 1
Mouse
Rat
Dog
regulator of calcineurin 1
Horse
regulator of calcineurin 1
Publication Statistics
PubMed Score 393.73
PubMed score by year
PubTator Score 191.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title