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Tbio
RBSN
Rabenosyn-5

Protein Summary
Description
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253699
  • ENSP00000253699
  • ENSG00000131381
  • ENST00000476527
  • ENSP00000422551

Symbol
  • ZFYVE20
  • ZFYVE20
  • Rabenosyn-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
protein domain
0.92
microRNA
0.84
transcription factor binding site profile
0.83
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
VPS45
Tbio
Novelty:  0.01960939
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EHD3
Tbio
Novelty:  0.02008691
p_int:  0.999999967
p_ni:  3.3e-8
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
EHD4
Tbio
Novelty:  0.04143584
p_int:  0.999940567
p_ni:  0.000059433
Score:  0.717
Data Source:  BioPlex,STRINGDB
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.999900663
p_ni:  0.000099337
Data Source:  BioPlex
PCDHA4
Tdark
Novelty:  0.30511211
p_int:  0.999894929
p_ni:  0.000105071
Data Source:  BioPlex
IFFO1
Tbio
Novelty:  0.38051741
p_int:  0.993149162
p_ni:  0.006849804
p_wrong:  0.000001034
Score:  0.161
Data Source:  BioPlex,STRINGDB
EHD1
Tbio
Novelty:  0.00817602
p_int:  0.97970087
p_ni:  0.02029913
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
p_int:  0.915447149
p_ni:  0.002957879
p_wrong:  0.081594972
Score:  0.186
Data Source:  BioPlex,STRINGDB
MUSK
Tchem
Family:  Kinase
Novelty:  0.00151518
p_int:  0.872421843
p_ni:  0.127296834
p_wrong:  0.000281323
Score:  0.352
Data Source:  BioPlex,STRINGDB
RAB4A
Tbio
Family:  Enzyme
Novelty:  0.00423197
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Toll Like Receptor 9 (TLR9) Cascade
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Innate Immune System
Toll Like Receptor 9 (TLR9) Cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rabenosyn, RAB effector
VGNC:12170
460201
Macaque
rabenosyn, RAB effector
702356
Mouse
MGI:1925537
78287
Rat
RGD:1305397
312562
Dog
rabenosyn, RAB effector
484642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rabenosyn, RAB effector
Macaque
rabenosyn, RAB effector
Mouse
Rat
Dog
rabenosyn, RAB effector
Publication Statistics
PubMed Score 177.34
PubMed score by year
PubTator Score 12.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title