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Tbio
RBPMS2
RNA-binding protein with multiple splicing 2

Protein Summary
Description
Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation. The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300069
  • ENSP00000300069
  • ENSG00000166831
  • ENST00000560606
  • ENSP00000456720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
tissue sample
0.68
PubMedID
0.55
transcription factor perturbation
0.54
small molecule perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.99999901
p_ni:  9.85e-7
p_wrong:  5e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.999862809
p_ni:  0.000137186
p_wrong:  6e-9
Score:  0.527
Data Source:  BioPlex,STRINGDB
DEFA6
Tbio
Novelty:  0.0363171
p_int:  0.999768427
p_ni:  0.000231573
Score:  0.189
Data Source:  BioPlex,STRINGDB
ESRP1
Tbio
Novelty:  0.02035464
p_int:  0.999339105
p_ni:  0.000093462
p_wrong:  0.000567432
Score:  0.909
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.998863148
p_ni:  0.001136852
Score:  0.58
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.997668661
p_ni:  0.002331339
Data Source:  BioPlex
LNX2
Tbio
Novelty:  0.03889661
Score:  0.639
Data Source:  STRINGDB
TOMM34
Tbio
Novelty:  0.05433718
Score:  0.634
Data Source:  STRINGDB
RBM24
Tbio
Novelty:  0.04562076
Score:  0.622
Data Source:  STRINGDB
DND1
Tbio
Novelty:  0.0287312
Score:  0.606
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
57.7
platelet count
1
1
1
56.8
electrocardiography
1
1
1
21.5
pulse pressure measurement
1
1
1
12.6
self reported educational attainment
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
57.7
platelet count
1
56.8
electrocardiography
1
21.5
pulse pressure measurement
1
12.6
self reported educational attainment
1
11.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein, mRNA processing factor 2
VGNC:13416
747918
Macaque
RNA binding protein with multiple splicing 2
712536
Mouse
MGI:1919223
71973
Rat
RGD:1561222
503214
Dog
RNA binding protein with multiple splicing 2
610746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein, mRNA processing factor 2
Macaque
RNA binding protein with multiple splicing 2
Mouse
Rat
Dog
RNA binding protein with multiple splicing 2
Publication Statistics
PubMed Score 7.38
PubMed score by year
PubTator Score 3.59
PubTator score by year
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Related Publications
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PMID
Year
Title