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Tbio
RBPMS
RNA-binding protein with multiple splicing

Protein Summary
Description
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287771
  • ENSP00000287771
  • ENSG00000157110
  • ENST00000320203
  • ENSP00000318102
  • ENST00000339877
  • ENSP00000340176
  • ENST00000397323
  • ENSP00000380486

Symbol
  • HERMES
  • HERMES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.93
disease perturbation
0.9
PubMedID
0.89
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
RBPMS2
Tbio
Novelty:  0.14005113
p_int:  0.99999901
p_ni:  9.85e-7
p_wrong:  5e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999981011
p_ni:  0.0000188
p_wrong:  1.89e-7
Score:  0.823
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.999887144
p_ni:  0.000112837
p_wrong:  1.9e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
ESRP1
Tbio
Novelty:  0.02035464
p_int:  0.999873654
p_ni:  0.000126346
Score:  0.809
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.998782153
p_ni:  0.001058401
p_wrong:  0.000159446
Data Source:  BioPlex
OLFM4
Tbio
Novelty:  0.01048505
p_int:  0.995719758
p_ni:  0.004137939
p_wrong:  0.000142303
Data Source:  BioPlex
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
p_int:  0.9874525
p_ni:  0.011844784
p_wrong:  0.000702716
Score:  0.199
Data Source:  BioPlex,STRINGDB
CRYBG2
Tdark
Novelty:  0.7500462
p_int:  0.941229842
p_ni:  0.028819561
p_wrong:  0.029950597
Data Source:  BioPlex
GSTZ1
Tbio
Family:  Enzyme
Novelty:  0.00929957
p_int:  0.916694443
p_ni:  0.083305557
Score:  0.528
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.792264263
p_ni:  0.002199841
p_wrong:  0.205535896
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
92.8
mean corpuscular volume
4
4
4
92.6
platelet crit
2
2
2
90.9
mosaic loss of chromosome Y measurement
3
2
3
90.2
neutrophil count
3
3
3
85.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
92.8
mean corpuscular volume
4
92.6
platelet crit
2
90.9
mosaic loss of chromosome Y measurement
3
90.2
neutrophil count
3
85.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein, mRNA processing factor
VGNC:50531
745703
Macaque
RNA binding protein with multiple splicing
694363
Mouse
MGI:1334446
19663
Rat
RGD:1561067
498642
Dog
RNA binding protein, mRNA processing factor
VGNC:45434
475599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein, mRNA processing factor
Macaque
RNA binding protein with multiple splicing
Mouse
Rat
Dog
RNA binding protein, mRNA processing factor
Publication Statistics
PubMed Score 64.85
PubMed score by year
PubTator Score 26.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title