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Tbio
RBP2
Retinol-binding protein 2

Protein Summary
Description
Intracellular transport of retinol. This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232217
  • ENSP00000232217
  • ENSG00000114113

Symbol
  • CRBP2
  • CRBP2
  • RBPC2
  • CRBPII
  • CRABP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.59
protein domain
0.58
disease
0.51
cell type or tissue
0.48
cell line
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.71   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.71   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.978
Data Source:  STRINGDB
RBP4
Tchem
Novelty:  0.00168442
Score:  0.965
Data Source:  STRINGDB
APOA4
Tbio
Novelty:  0.00305835
Score:  0.941
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.941
Data Source:  STRINGDB
RDH8
Tbio
Family:  Enzyme
Novelty:  0.06071472
Score:  0.937
Data Source:  STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
Score:  0.928
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.925
Data Source:  Reactome,STRINGDB
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
Score:  0.924
Data Source:  STRINGDB
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
Score:  0.919
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
5.6
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 2
VGNC:2533
743813
Mouse
MGI:97877
19660
Rat
RGD:3544
24710
Dog
retinol binding protein 2
VGNC:45430
477089
Horse
retinol binding protein 2
VGNC:22255
100051689
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 2
Mouse
Rat
Dog
retinol binding protein 2
Horse
retinol binding protein 2
Publication Statistics
PubMed Score 124.71
PubMed score by year
PubTator Score 63.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title