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Tbio
RBMS1
RNA-binding motif, single-stranded-interacting protein 1

Protein Summary
Description
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348849
  • ENSP00000294904
  • ENSG00000153250

Symbol
  • C2orf12
  • MSSP
  • MSSP1
  • SCR2
  • YC1
  • MSSP
  • SCR2
  • HCC-4
  • MSSP-1
  • MSSP-2
  • MSSP-3
  • C2orf12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.97
disease perturbation
0.96
PubMedID
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999776287
p_ni:  0.000223713
Data Source:  BioPlex
AGO1
Tbio
Novelty:  0.00157424
p_int:  0.983330347
p_ni:  0.013018736
p_wrong:  0.003650917
Score:  0.235
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.964181805
p_ni:  0.035818195
Score:  0.156
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.962481953
p_ni:  0.037517528
p_wrong:  5.19e-7
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.947564743
p_ni:  0.052151272
p_wrong:  0.000283985
Data Source:  BioPlex
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.939605944
p_ni:  0.06017127
p_wrong:  0.000222786
Data Source:  BioPlex
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.926717531
p_ni:  0.072608304
p_wrong:  0.000674165
Score:  0.178
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.922566614
p_ni:  0.075691437
p_wrong:  0.001741949
Score:  0.152
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.905535163
p_ni:  0.093633885
p_wrong:  0.000830953
Data Source:  BioPlex
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
p_int:  0.900375407
p_ni:  0.098553875
p_wrong:  0.001070718
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
93.7
lymphocyte percentage of leukocytes
2
2
2
90.3
5
5
3
1.1
79
leukocyte count
2
1
2
74.6
BMI-adjusted hip circumference
1
5
5
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
93.7
lymphocyte percentage of leukocytes
2
90.3
3
1.1
79
leukocyte count
2
74.6
BMI-adjusted hip circumference
5
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RNA binding motif single stranded interacting protein 1
703608
Mouse
MGI:1861774
56878
Rat
RGD:1307777
362138
Dog
RNA binding motif single stranded interacting protein 1
VGNC:45427
478764
Horse
RNA binding motif single stranded interacting protein 1
VGNC:22253
100060392
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RNA binding motif single stranded interacting protein 1
Mouse
Rat
Dog
RNA binding motif single stranded interacting protein 1
Horse
RNA binding motif single stranded interacting protein 1
Publication Statistics
PubMed Score 205.90
PubMed score by year
PubTator Score 180.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title