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Tbio
RBM8A
RNA-binding protein 8A

Protein Summary
Description
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369307
  • ENSP00000358313
  • ENSG00000265241
  • ENST00000583313
  • ENSP00000463058
  • ENST00000632555
  • ENSP00000488265

Symbol
  • RBM8
  • TAR
  • Y14
  • RBM8
  • ZNRP
  • RBM8B
  • ZRNP1
  • BOV-1A
  • BOV-1B
  • BOV-1C
  • MDS014
  • DEL1q21.1
  • C1DELq21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.93
virus perturbation
0.88
co-expressed gene
0.85
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2390.37   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2390.37   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0