You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RBM8A
RNA-binding protein 8A

Protein Summary
Description
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369307
  • ENSP00000358313
  • ENSG00000265241
  • ENST00000583313
  • ENSP00000463058
  • ENST00000632555
  • ENSP00000488265

Symbol
  • RBM8
  • TAR
  • Y14
  • RBM8
  • ZNRP
  • RBM8B
  • ZRNP1
  • BOV-1A
  • BOV-1B
  • BOV-1C
  • MDS014
  • DEL1q21.1
  • C1DELq21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.93
virus perturbation
0.88
co-expressed gene
0.85
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1962.71   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1962.71   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (465)
PYM1
Tbio
Novelty:  0.04117785
p_int:  0.999701265
p_ni:  0.000298735
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAGOH
Tbio
Novelty:  0.03637008
p_int:  0.999180022
p_ni:  0.000819978
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
UPF3B
Tbio
Novelty:  0.03482348
Score:  0.999
Data Source:  Reactome,STRINGDB
MAGOHB
Tbio
Novelty:  0.03749676
Score:  0.999
Data Source:  Reactome,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
Score:  0.999
Data Source:  STRINGDB
UPF3A
Tbio
Novelty:  0.01431609
Score:  0.999
Data Source:  Reactome,STRINGDB
SRSF1
Tbio
Novelty:  0.00074446
Score:  0.999
Data Source:  STRINGDB
NXF1
Tbio
Novelty:  0.00642439
Score:  0.999
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.999
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Gene expression (Transcription)
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
4
4
91.9
myeloid white cell count
1
1
1
68.8
granulocyte count
1
1
1
46.9
high density lipoprotein cholesterol measurement
1
1
1
40.7
apolipoprotein A 1 measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
91.9
myeloid white cell count
1
68.8
granulocyte count
1
46.9
high density lipoprotein cholesterol measurement
1
40.7
apolipoprotein A 1 measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913129
60365
Rat
RGD:1310099
295284
Dog
RNA binding motif protein 8A
VGNC:45426
475827
Horse
RNA binding motif protein 8A
VGNC:22252
100034052
Cow
RNA binding motif protein 8A
VGNC:33808
518045
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RNA binding motif protein 8A
Horse
RNA binding motif protein 8A
Cow
RNA binding motif protein 8A
Publication Statistics
PubMed Score 1962.71
PubMed score by year
PubTator Score 172.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title