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Tdark
RBM4B
RNA-binding protein 4B

Protein Summary
Description
Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310046
  • ENSP00000310471
  • ENSG00000173914
  • ENST00000525754
  • ENSP00000433071

Symbol
  • RBM30
  • RBM30
  • RBM4L
  • ZCRB3B
  • ZCCHC15
  • ZCCHC21B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor binding site profile
0.85
disease perturbation
0.74
histone modification site profile
0.72
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.99999637
p_ni:  0.00000363
Data Source:  BioPlex
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.999561062
p_ni:  0.000438938
Score:  0.856
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.990058089
p_ni:  0.009941911
Score:  0.547
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.98824211
p_ni:  0.011757888
p_wrong:  2e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.986755742
p_ni:  0.013240339
p_wrong:  0.000003919
Score:  0.799
Data Source:  BioPlex,STRINGDB
HASPIN
Tchem
Family:  Kinase
Novelty:  0.01574198
p_int:  0.981268672
p_ni:  0.018277944
p_wrong:  0.000453384
Data Source:  BioPlex
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.978414146
p_ni:  0.021585854
Data Source:  BioPlex
MYEF2
Tdark
Novelty:  0.33569061
p_int:  0.977815779
p_ni:  0.022184221
Score:  0.249
Data Source:  BioPlex,STRINGDB
TOP2A
Tclin
Family:  Enzyme
Novelty:  0.00122788
p_int:  0.957488502
p_ni:  0.011007899
p_wrong:  0.031503599
Score:  0.181
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.945716709
p_ni:  0.054283291
Score:  0.536
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
PI3K-Akt Signaling Pathway
WikiPathways
Ras Signaling
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
Circadian rhythm related genes
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
PI3K-Akt Signaling Pathway
Ras Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
2
2
89.1
insomnia measurement
1
2
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
46.9
IGF-1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
89.1
insomnia measurement
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
49.5
apolipoprotein B measurement
1
46.9
IGF-1 measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 4B
VGNC:11676
451351
Mouse
MGI:1913954
66704
Rat
RGD:1359343
474154
Dog
RNA binding motif protein 4B
VGNC:52038
476008
Cow
RNA binding motif protein 4B
505756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 4B
Mouse
Rat
Dog
RNA binding motif protein 4B
Cow
RNA binding motif protein 4B
Publication Statistics
PubMed Score 2.01
PubMed score by year
PubTator Score 2.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title