You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RBM4
RNA-binding protein 4

Protein Summary
Description
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310092
  • ENSP00000309166
  • ENSG00000173933
  • ENST00000396053
  • ENSP00000413497
  • ENST00000398692
  • ENSP00000381680
  • ENST00000408993
  • ENSP00000386561
  • ENST00000409406
  • ENSP00000386894
  • ENST00000483858
  • ENSP00000435821
  • ENST00000530235
  • ENSP00000432150
  • ENST00000532968
  • ENSP00000432020

Symbol
  • RBM4A
  • LARK
  • RBM4A
  • ZCRB3A
  • ZCCHC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
biological process
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.05   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.05   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
WDR3
Tbio
Novelty:  0.15410886
p_int:  0.999720395
p_ni:  0.000279349
p_wrong:  2.55e-7
Data Source:  BioPlex
RBM4B
Tdark
Novelty:  0.33151475
p_int:  0.999561062
p_ni:  0.000438938
Score:  0.856
Data Source:  BioPlex,STRINGDB
ZNF420
Tbio
Family:  TF
Novelty:  0.20022795
p_int:  0.99948441
p_ni:  0.000021825
p_wrong:  0.000493765
Data Source:  BioPlex
WDR36
Tbio
Novelty:  0.02010676
p_int:  0.998030079
p_ni:  0.001969896
p_wrong:  2.5e-8
Data Source:  BioPlex
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.997959974
p_ni:  0.002025557
p_wrong:  0.000014468
Score:  0.181
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.997608529
p_ni:  0.002391471
Score:  0.22
Data Source:  BioPlex,STRINGDB
WDR43
Tbio
Novelty:  0.12680949
p_int:  0.997174228
p_ni:  0.002825768
p_wrong:  4e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.995253308
p_ni:  0.004746692
Score:  0.311
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.994063511
p_ni:  0.005936482
p_wrong:  7e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
CENPC
Tbio
Novelty:  0.00638662
p_int:  0.993813045
p_ni:  0.006186931
p_wrong:  2.3e-8
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
2
2
89.1
insomnia measurement
1
2
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
46.9
IGF-1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
89.1
insomnia measurement
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
49.5
apolipoprotein B measurement
1
46.9
IGF-1 measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 4
100611312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 4
Publication Statistics
PubMed Score 60.05
PubMed score by year
PubTator Score 92.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title