Tbio RBM38 RNA-binding protein 38

Protein Summary

Description

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.

Uniprot Accession IDs

• Q9H0Z9
• A6NDK1
• A6NMU6
• Q15350
• Q15351
• Q9BYK3
• Q9BYK4

Gene Name

• RBM38

Ensembl ID

• ENST00000356208
• ENSP00000348538
• ENSG00000132819
• ENST00000440234
• ENSP00000407848

Symbol

• RNPC1
• SEB4
• RNPC1
• SEB4B
• SEB4D
• HSRNASEB
• dJ800J21.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.86
transcription factor perturbation	0.84
transcription factor	0.7
tissue sample	0.64
disease	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.65   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.65   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0