Tdark RBM34 RNA-binding protein 34

Protein Summary

Description

This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P42696
• A8K8J7
• Q8N2Z8
• Q9H5A1

Gene Name

• RBM34

Ensembl ID

• ENST00000408888
• ENSP00000386226
• ENSG00000188739

Symbol

• KIAA0117

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
interacting protein	0.87
transcription factor binding site profile	0.86
microRNA	0.66
tissue sample	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (270)

Explore Interacting Targets

1 – 10 of 270

• See Interactions on String-DB

HIST2H2BF

Tdark

Novelty:  1.40321359

p_int:  0.999998581

p_ni:  7e-9

p_wrong:  0.000001412

Score:  0.187

Data Source:  BioPlex,STRINGDB

CENPI

Tbio

Novelty:  0.01938121

p_int:  0.999795869

p_ni:  0.000204131

Score:  0.228

Data Source:  BioPlex,STRINGDB

CENPC

Tbio

Novelty:  0.00638662

p_int:  0.999439341

p_ni:  0.000560652

p_wrong:  7e-9

Score:  0.268

Data Source:  BioPlex,STRINGDB

RPL36AL

Tbio

Novelty:  0.09336423

p_int:  0.999190233

p_ni:  0.000809734

p_wrong:  3.3e-8

Score:  0.225

Data Source:  BioPlex,STRINGDB

SDAD1

Tdark

Novelty:  0.2574139

p_int:  0.998287655

p_ni:  0.001712345

Score:  0.882

Data Source:  BioPlex,STRINGDB

PUM3

Tbio

Novelty:  0.02344206

p_int:  0.996644852

p_ni:  0.003355148

Score:  0.95

Data Source:  BioPlex,STRINGDB

TAF1D

Tdark

Family:  Enzyme

Novelty:  0.26072519

p_int:  0.995925896

p_ni:  0.004074101

p_wrong:  3e-9

Score:  0.554

Data Source:  BioPlex,STRINGDB

RRP8

Tbio

Family:  Enzyme

Novelty:  0.04922797

p_int:  0.995448092

p_ni:  0.004551908

Score:  0.781

Data Source:  BioPlex,STRINGDB

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.993929147

p_ni:  0.006070853

Score:  0.397

Data Source:  BioPlex,STRINGDB

RPL30

Tbio

Novelty:  0.0134194

p_int:  0.992378604

p_ni:  0.007621396

Score:  0.532

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (2)

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1	1	1		68.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1		68.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
monocyte percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RNA binding motif protein 34	VGNC:1483	107970653
Mouse	RNA binding motif protein 34	MGI:1098653	52202
Rat	RNA binding motif protein 34	RGD:1310161	307956
Dog	RNA binding motif protein 34	VGNC:45419	479199
Horse	RNA binding motif protein 34	VGNC:22242	100146167

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RNA binding motif protein 34
Mouse	RNA binding motif protein 34
Rat	RNA binding motif protein 34
Dog	RNA binding motif protein 34
Horse	RNA binding motif protein 34

Publication Statistics

PubMed Score 1.43

PubMed score by year

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PubTator Score 1.00

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title