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Tbio
RBM3
RNA-binding protein 3

Protein Summary
Description
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376755
  • ENSP00000365946
  • ENSG00000102317
  • ENST00000376759
  • ENSP00000365950

Symbol
  • RNPL
  • RNPL
  • IS1-RNPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus perturbation
0.99
disease perturbation
0.83
transcription factor binding site profile
0.82
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.45   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.45   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.995667683
p_ni:  0.004332317
Score:  0.2
Data Source:  BioPlex,STRINGDB
SUPV3L1
Tbio
Family:  Enzyme
Novelty:  0.01598799
p_int:  0.992263846
p_ni:  0.007736154
Score:  0.19
Data Source:  BioPlex,STRINGDB
MCAT
Tbio
Family:  Enzyme
Novelty:  0.00600508
p_int:  0.98638363
p_ni:  0.01361637
Score:  0.167
Data Source:  BioPlex,STRINGDB
PAIP2B
Tbio
Novelty:  0.65592664
p_int:  0.98172179
p_ni:  0.014656992
p_wrong:  0.003621218
Score:  0.201
Data Source:  BioPlex,STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.963696857
p_ni:  0.036303142
Score:  0.16
Data Source:  BioPlex,STRINGDB
NGRN
Tbio
Novelty:  0.11162143
p_int:  0.914920285
p_ni:  0.085079673
p_wrong:  4.2e-8
Data Source:  BioPlex
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.884418186
p_ni:  0.115581814
Data Source:  BioPlex
NIF3L1
Tbio
Novelty:  0.15581813
p_int:  0.867740057
p_ni:  0.132247819
p_wrong:  0.000012124
Score:  0.175
Data Source:  BioPlex,STRINGDB
AARS2
Tbio
Family:  Enzyme
Novelty:  0.01309387
p_int:  0.834166828
p_ni:  0.165833172
Score:  0.176
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.75982562
p_ni:  0.24017438
Score:  0.228
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 3
VGNC:49019
465617
Mouse
MGI:1099460
19652
Rat
RGD:620145
114488
Dog
RNA binding motif protein 3
609457
Horse
RNA binding motif protein 3
VGNC:52426
100051736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 3
Mouse
Rat
Dog
RNA binding motif protein 3
Horse
RNA binding motif protein 3
Publication Statistics
PubMed Score 136.45
PubMed score by year
PubTator Score 49.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title