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Tbio
RBM28
RNA-binding protein 28

Protein Summary
Description
Nucleolar component of the spliceosomal ribonucleoprotein complexes. The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223073
  • ENSP00000223073
  • ENSG00000106344
  • ENST00000415472
  • ENSP00000390517

Symbol
  • ANES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
kinase perturbation
0.84
transcription factor perturbation
0.74
transcription factor binding site profile
0.73
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (318)
REXO4
Tbio
Family:  Enzyme
Novelty:  0.0328295
p_int:  0.999432554
p_ni:  0.000567446
Score:  0.786
Data Source:  BioPlex,STRINGDB
NAT10
Tbio
Family:  Enzyme
Novelty:  0.02453679
p_int:  0.991757112
p_ni:  0.008242889
Score:  0.935
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.986442314
p_ni:  0.013557673
p_wrong:  1.3e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.975697418
p_ni:  0.024302582
Score:  0.566
Data Source:  BioPlex,STRINGDB
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.964168474
p_ni:  0.035831521
p_wrong:  5e-9
Data Source:  BioPlex
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.963057794
p_ni:  0.036942206
Score:  0.534
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.958878423
p_ni:  0.041121577
Score:  0.178
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.956767609
p_ni:  0.043232391
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.955774257
p_ni:  0.044225744
Score:  0.986
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.954896238
p_ni:  0.045103762
Score:  0.405
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted leptin measurement
10
3
13
87.7
leptin measurement
7
3
8
70.2
pelvic organ prolapse
1
1
0
1.3
53.3
2
1
0
1.1
12.8
high density lipoprotein cholesterol measurement
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted leptin measurement
13
87.7
leptin measurement
8
70.2
pelvic organ prolapse
0
1.3
53.3
0
1.1
12.8
high density lipoprotein cholesterol measurement
1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 28
VGNC:4488
739989
Macaque
RNA binding motif protein 28
698858
Mouse
MGI:2655711
68272
Rat
RGD:1311336
312182
Dog
RNA binding motif protein 28
VGNC:45417
475203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 28
Macaque
RNA binding motif protein 28
Mouse
Rat
Dog
RNA binding motif protein 28
Publication Statistics
PubMed Score 8.49
PubMed score by year
PubTator Score 5.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title