Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

RBM27

Ensembl ID

ENST00000265271
ENSP00000265271
ENSG00000091009

Symbol

KIAA1311
Psc1
ARRS1
ZC3H18
ZC3H20

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94

microRNA	0.76

histone modification site profile	0.72

tissue sample	0.65

transcription factor	0.63

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 29 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 29 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

See Interactions on String-DB

PRM2

Tbio

Novelty: 0.0050028

p_int: 0.999998079

p_ni: 0.000001921

Data Source: BioPlex

CHCHD10

Tbio

Novelty: 0.01659548

p_int: 0.999992115

p_ni: 0.000007885

Data Source: BioPlex

TNFRSF13B

Tbio

Novelty: 0.00338954

p_int: 0.999986069

p_ni: 0.000013931

Data Source: BioPlex

CHCHD2

Tbio

Novelty: 0.01615338

p_int: 0.99991947

p_ni: 0.000080528

p_wrong: 2e-9

Data Source: BioPlex

RNASEH1

Tchem

Family: Enzyme

Novelty: 0.01838314

p_int: 0.999915822

p_ni: 0.000084178

Data Source: BioPlex

SRPK1

Tchem

Family: Kinase

Novelty: 0.01066655

p_int: 0.999602517

p_ni: 0.000397482

p_wrong: 1e-9

Score: 0.444

Data Source: BioPlex,STRINGDB

LUC7L

Tbio

Novelty: 0.05748021

p_int: 0.998308248

p_ni: 0.001691752

Score: 0.261

Data Source: BioPlex,STRINGDB

CLEC3A

Tdark

Novelty: 0.21498836

p_int: 0.996857457

p_ni: 0.003142516

p_wrong: 2.7e-8

Data Source: BioPlex

DUSP23

Tbio

Family: Enzyme

Novelty: 0.06522366

p_int: 0.988069515

p_ni: 0.011930485

Score: 0.186

Data Source: BioPlex,STRINGDB

GTF3C2

Tdark

Novelty: 0.1827844

p_int: 0.985419518

p_ni: 0.014568313

p_wrong: 0.000012169

Score: 0.2

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	2	1	2		42.3

Alzheimer's disease	EFO_0000249	1	1	0	5.5	15.8

age at onset	EFO_0004847	1	1	0	5.5	15.8

mathematical ability	EFO_0004875	1	1	1		8.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	2		42.3

Alzheimer's disease	EFO_0000249	0	5.5	15.8

age at onset	EFO_0004847	0	5.5	15.8

mathematical ability	EFO_0004875	1		8.9

Beta Count

Odds Ratio

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UniProt Keyword

Find Similar Targets

No Header	No Header
Coiled coil

Complete proteome

Cytoplasm

Metal-binding

Methylation

Nucleus

Phosphoprotein

Reference proteome

RNA-binding

Zinc

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID
Chimp	RNA binding motif protein 27		471684

Macaque	-

Mouse	RNA binding motif protein 27	MGI:2147194	225432

Rat	RNA binding motif protein 27	RGD:1311966	361317

Dog	RNA binding motif protein 27		487199

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RNA binding motif protein 27

Macaque	-

Mouse	RNA binding motif protein 27

Rat	RNA binding motif protein 27

Dog	RNA binding motif protein 27

Publication Statistics

PubMed Score 23.57

PubMed score by year

PubTator Score 2.70

PubTator score by year

Related Publications

Text Mined References (12)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title