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Tbio
RBM25
RNA-binding protein 25

Protein Summary
Description
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261973
  • ENSP00000261973
  • ENSG00000119707
  • ENST00000525321
  • ENSP00000436868
  • ENST00000526754
  • ENSP00000436225
  • ENST00000527432
  • ENSP00000431150
  • ENST00000528081
  • ENSP00000434444

Symbol
  • RNPC7
  • S164
  • NET52
  • RNPC7
  • Snu71
  • RED120
  • fSAP94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.91
histone modification site profile
0.83
microRNA
0.81
hub protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.03   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.03   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (315)
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.999999941
p_ni:  6e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
RGS9
Tbio
Novelty:  0.06662559
p_int:  0.999958868
p_ni:  0.000041132
Score:  0.861
Data Source:  BioPlex,STRINGDB
ATP6V1G2
Tbio
Family:  Enzyme
Novelty:  0.10663259
p_int:  0.999956729
p_ni:  0.000043264
p_wrong:  7e-9
Data Source:  BioPlex
PRPF40B
Tdark
Novelty:  0.04278291
p_int:  0.99964384
p_ni:  0.000356141
p_wrong:  2e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
SLC30A4
Tbio
Family:  Transporter
Novelty:  0.02209
p_int:  0.999250705
p_ni:  0.000749295
Score:  0.213
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.99919627
p_ni:  0.00080373
Score:  0.27
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.994267868
p_ni:  0.005732132
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.992941967
p_ni:  0.007058033
Score:  0.549
Data Source:  BioPlex,STRINGDB
NKAP
Tbio
Novelty:  0.04982584
p_int:  0.949365493
p_ni:  0.050634507
Score:  0.729
Data Source:  BioPlex,STRINGDB
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.898710322
p_ni:  0.101289678
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
3
3
90.1
red blood cell density measurement
1
1
1
75.7
C-reactive protein measurement
1
1
1
72.3
HbA1c measurement
1
1
1
47.7
cognitive function measurement
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
90.1
red blood cell density measurement
1
75.7
C-reactive protein measurement
1
72.3
HbA1c measurement
1
47.7
cognitive function measurement
2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 25
VGNC:3330
453012
Macaque
RNA binding motif protein 25
695911
Mouse
MGI:1914289
67039
Horse
RNA binding motif protein 25
VGNC:22239
100055577
Cow
RNA binding motif protein 25
VGNC:33794
540258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 25
Macaque
RNA binding motif protein 25
Mouse
Horse
RNA binding motif protein 25
Cow
RNA binding motif protein 25
Publication Statistics
PubMed Score 19.03
PubMed score by year
PubTator Score 44.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title