You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RBM24
RNA-binding protein 24

Protein Summary
Description
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318204
  • ENSP00000319551
  • ENSG00000112183
  • ENST00000379052
  • ENSP00000368341
  • ENST00000425446
  • ENSP00000396898

Symbol
  • RNPC6
  • RNPC6
  • dJ259A10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.74
histone modification site profile
0.72
microRNA
0.71
tissue sample
0.61
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
RBM38
Tbio
Novelty:  0.03491566
p_int:  0.999997915
p_ni:  0.000002076
p_wrong:  8e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
DMKN
Tbio
Novelty:  0.08303199
p_int:  0.999491475
p_ni:  0.000042301
p_wrong:  0.000466223
Score:  0.214
Data Source:  BioPlex,STRINGDB
IVL
Tbio
Novelty:  0.00147892
p_int:  0.999196487
p_ni:  0.000803506
p_wrong:  7e-9
Data Source:  BioPlex
TRIM29
Tbio
Novelty:  0.02572789
p_int:  0.998813376
p_ni:  0.001186623
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.998637066
p_ni:  0.001358526
p_wrong:  0.000004409
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.998406023
p_ni:  0.001593977
Data Source:  BioPlex
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.99785669
p_ni:  0.00214331
Score:  0.169
Data Source:  BioPlex,STRINGDB
PKP3
Tbio
Novelty:  0.0269462
p_int:  0.997821465
p_ni:  0.002177039
p_wrong:  0.000001496
Data Source:  BioPlex
PPL
Tbio
Novelty:  0.00684645
p_int:  0.996926543
p_ni:  0.003073457
Score:  0.158
Data Source:  BioPlex,STRINGDB
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.995312346
p_ni:  0.004687635
p_wrong:  1.9e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 24
VGNC:11202
750853
Macaque
RNA binding motif protein 24
703328
Mouse
MGI:3610364
666794
Rat
RGD:1584029
690139
Horse
RNA binding motif protein 24
100051943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 24
Macaque
RNA binding motif protein 24
Mouse
Rat
Horse
RNA binding motif protein 24
Publication Statistics
PubMed Score 32.38
PubMed score by year
PubTator Score 7.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title