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Tbio
RBM23
Probable RNA-binding protein 23

Protein Summary
Description
Probable RNA-binding protein. May be involved in pre-mRNA splicing process. This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346528
  • ENSP00000339220
  • ENSG00000100461
  • ENST00000359890
  • ENSP00000352956
  • ENST00000399922
  • ENSP00000382806

Symbol
  • RNPC4
  • PP239
  • RNPC4
  • CAPERbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.69
tissue
0.67
cell line
0.63
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999998965
p_ni:  0.000001033
p_wrong:  3e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999994662
p_ni:  0.000005338
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999810582
p_ni:  0.000189417
Score:  0.193
Data Source:  BioPlex,STRINGDB
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.999735231
p_ni:  0.000264764
p_wrong:  4e-9
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999697781
p_ni:  0.000302216
p_wrong:  3e-9
Data Source:  BioPlex
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.999323384
p_ni:  0.000676614
p_wrong:  2e-9
Data Source:  BioPlex
TNFRSF13B
Tbio
Novelty:  0.00338954
p_int:  0.998608898
p_ni:  0.001391092
p_wrong:  1e-8
Data Source:  BioPlex
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.998172183
p_ni:  0.001827817
Score:  0.407
Data Source:  BioPlex,STRINGDB
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.998065945
p_ni:  0.001933673
p_wrong:  3.82e-7
Data Source:  BioPlex
SCRIB
Tbio
Novelty:  0.01099525
p_int:  0.995464025
p_ni:  0.004535975
Score:  0.178
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
3
4
86.7
heel bone mineral density
3
1
3
81.2
cup-to-disc ratio measurement
2
2
2
78.7
Dupuytren Contracture
1
1
0
1.3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.7
91
mathematical ability
4
86.7
heel bone mineral density
3
81.2
cup-to-disc ratio measurement
2
78.7
Dupuytren Contracture
0
1.3
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 23
VGNC:3331
467400
Macaque
RNA binding motif protein 23
712650
Dog
RNA binding motif protein 23
VGNC:51678
480241
Horse
RNA binding motif protein 23
VGNC:51654
100052786
Cow
RNA binding motif protein 23
VGNC:52812
513711
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 23
Macaque
RNA binding motif protein 23
Dog
RNA binding motif protein 23
Horse
RNA binding motif protein 23
Cow
RNA binding motif protein 23
Publication Statistics
PubMed Score 18.50
PubMed score by year
PubTator Score 3.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title