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Tbio
RBKS
Ribokinase

Protein Summary
Description
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302188
  • ENSP00000306817
  • ENSG00000171174

Symbol
  • RBSK
  • RK
  • RBSK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.87
transcription factor binding site profile
0.79
protein domain
0.73
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
p_int:  0.829898124
p_ni:  0.170101876
Score:  0.696
Data Source:  BioPlex,STRINGDB
RPIA
Tbio
Family:  Enzyme
Novelty:  0.00968705
Score:  0.985
Data Source:  STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
Score:  0.969
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.968
Data Source:  STRINGDB
PGM2
Tbio
Family:  Enzyme
Novelty:  0.00922421
Score:  0.958
Data Source:  STRINGDB
PRPS1L1
Tdark
Family:  Kinase
Novelty:  0.02527534
Score:  0.958
Data Source:  STRINGDB
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
Score:  0.953
Data Source:  STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
Score:  0.949
Data Source:  STRINGDB
TKTL1
Tbio
Family:  Enzyme
Novelty:  0.01464511
Score:  0.946
Data Source:  STRINGDB
PRPS2
Tbio
Family:  Kinase
Novelty:  0.02472415
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
7
7
97
hematocrit
3
3
3
91.4
C-reactive protein measurement
2
4
4
90.4
apolipoprotein B measurement
1
2
2
71.1
serum gamma-glutamyl transferase measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
97
hematocrit
3
91.4
C-reactive protein measurement
4
90.4
apolipoprotein B measurement
2
71.1
serum gamma-glutamyl transferase measurement
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribokinase
VGNC:349
100613803
Macaque
ribokinase
702464
Mouse
MGI:1918586
71336
Rat
RGD:1310064
362706
Dog
ribokinase
VGNC:45401
475710
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribokinase
Macaque
ribokinase
Mouse
Rat
Dog
ribokinase
Publication Statistics
PubMed Score 57.04
PubMed score by year
PubTator Score 3.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title