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Tbio
RBFOX3
RNA binding protein fox-1 homolog 3

Protein Summary
Description
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000580155
  • ENSP00000463653
  • ENSG00000167281
  • ENST00000584778
  • ENSP00000462007

Symbol
  • FOX3
  • NEUN
  • FOX-3
  • HRNBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
disease
0.68
cell type or tissue
0.63
cell line
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2438.47   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2438.47   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (237)
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999997977
p_ni:  0.000002023
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC2A5
Tbio
Family:  Transporter
Novelty:  0.0032733
p_int:  0.989334196
p_ni:  0.010662114
p_wrong:  0.00000369
Score:  0.327
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.978317627
p_ni:  0.021681414
p_wrong:  9.59e-7
Data Source:  BioPlex
PLPP4
Tbio
Family:  Enzyme
Novelty:  0.22418589
p_int:  0.794072702
p_ni:  0.205338598
p_wrong:  0.000588701
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
Score:  0.938
Data Source:  STRINGDB
RBM24
Tbio
Novelty:  0.04562076
Score:  0.896
Data Source:  STRINGDB
DCX
Tbio
Novelty:  0.00077614
Score:  0.894
Data Source:  STRINGDB
AIF1
Tbio
Novelty:  0.00049167
Score:  0.894
Data Source:  STRINGDB
NES
Tbio
Novelty:  0.00035379
Score:  0.84
Data Source:  STRINGDB
SYP
Tbio
Novelty:  0.00021543
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
1
1
0
1.5
28.1
disease progression measurement
1
1
0
7.9
24.5
metastasis measurement
1
1
0
7.9
24.5
Oral cleft
1
1
1
17.8
body mass index
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
0
1.5
28.1
disease progression measurement
0
7.9
24.5
metastasis measurement
0
7.9
24.5
Oral cleft
1
17.8
body mass index
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 3
VGNC:12643
454933
Mouse
MGI:106368
52897
Rat
RGD:1560070
287847
Dog
RNA binding fox-1 homolog 3
VGNC:45400
608803
Horse
RNA binding fox-1 homolog 3
VGNC:22227
100050497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 3
Mouse
Rat
Dog
RNA binding fox-1 homolog 3
Horse
RNA binding fox-1 homolog 3
Publication Statistics
PubMed Score 2438.47
PubMed score by year
PubTator Score 345.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title